Literature DB >> 10090903

A note on power approximations for the transmission/disequilibrium test.

M Knapp1.   

Abstract

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.

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Year:  1999        PMID： 10090903      PMCID： PMC1377842          DOI： 10.1086/302334

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  6 in total

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  6 in total
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Journal:  Genes Immun       Date:  2007-08-23       Impact factor: 2.676
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