BACKGROUND: Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide attempts. METHODS: The TPH intron 7 A218C polymorphism was determined using a polymerase chain reaction-based method in DNA samples from 152 patients with bipolar disorder and 94 healthy control subjects. RESULTS: There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior. CONCLUSIONS: This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls.
BACKGROUND: Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide attempts. METHODS: The TPH intron 7 A218C polymorphism was determined using a polymerase chain reaction-based method in DNA samples from 152 patients with bipolar disorder and 94 healthy control subjects. RESULTS: There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior. CONCLUSIONS: This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls.
Authors: Susanne M Brunner; Aitak Farzi; Felix Locker; Barbara S Holub; Meinrad Drexel; Florian Reichmann; Andreas A Lang; Johannes A Mayr; Jorge J Vilches; Xavier Navarro; Roland Lang; Günther Sperk; Peter Holzer; Barbara Kofler Journal: Proc Natl Acad Sci U S A Date: 2014-04-29 Impact factor: 11.205
Authors: Jiajun Shi; Judith A Badner; Eiji Hattori; James B Potash; Virginia L Willour; Francis J McMahon; Elliot S Gershon; Chunyu Liu Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-10-05 Impact factor: 3.568
Authors: Judah D Weathers; Argyris Stringaris; Christen M Deveney; Melissa A Brotman; Carlos A Zarate; Megan E Connolly; Stephen J Fromm; Stephanie B LeBourdais; Daniel S Pine; Ellen Leibenluft Journal: Am J Psychiatry Date: 2012-06 Impact factor: 18.112
Authors: Fayaz Seifuddin; Pamela Belmonte Mahon; Jennifer Judy; Mehdi Pirooznia; Dubravka Jancic; Jacob Taylor; Fernando S Goes; James B Potash; Peter P Zandi Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2012-05-09 Impact factor: 3.568