Literature DB >> 100783

High concentration of thyrotropin-releasing hormone in pancreatic islets.

E Martino, A Lernmark, H Seo, D F Steiner, S Refetoff.   

Abstract

The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of islet TRH is unknown. However, because TRH is antagonistic to somatostatin in other systems, and somatostatin also is concentrated in islets in high concentrations, it is possible that islet TRH may serve a similar antagonistic function in the regulation of islet cell secretory activity.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 100783      PMCID： PMC336093          DOI： 10.1073/pnas.75.9.4265

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Evidence for the D-cell of the pancreas secreting somatostatin.

Authors:  L Orci; D Baetens; M P Dubois; C Rufener
Journal:  Horm Metab Res       Date:  1975-09       Impact factor: 2.936

2.  Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

Authors:  M P Dubois
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

3.  Loss of bioreactivity and preservation of immunoreactivity of iodothyrotropin-releasing hormone.

Authors:  E Martino; H Seo; S Refetoff
Journal:  Endocrinology       Date:  1978-07       Impact factor: 4.736

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting.

Authors:  J M Schaeffer; M J Brownstein; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

6.  In vitro biosynthesis of TSH- and LH-releasing factors by the human placenta.

Authors:  J M Gibbons; M Mitnick; V Chieffo
Journal:  Am J Obstet Gynecol       Date:  1975-01-01       Impact factor: 8.661

7.  The identification of thyrotropin releasing hormone (TRH) in hypothalamic and extrahypothalamic loci of the human nervous system.

Authors:  M J Kubek; M A Lorincz; J F Wilber
Journal:  Brain Res       Date:  1977-04-22       Impact factor: 3.252

8.  Thyrotropin-releasing hormone content of rat brain and hypothalamus: results of endocrine and pharmacologic treatments.

Authors:  F Kardon; R J Marcus; A Winokur; R D Utiger
Journal:  Endocrinology       Date:  1977-06       Impact factor: 4.736

9.  Pituitary and extrapituitary effects of somatostatin in normal man.

Authors:  G Copinschi; V Leclercq-Meyer; E Virasoro; M L'Hermite; L Vanhaelst; J Golstein; R Leclercq; F Féry; C Robyn
Journal:  Horm Metab Res       Date:  1976-05       Impact factor: 2.936

10.  Increased somatostatin content of islets from streptozotocin-diabetic rats.

Authors:  Y C Patel; G C Weir
Journal:  Clin Endocrinol (Oxf)       Date:  1976-03       Impact factor: 3.478
View more
  20 in total

1.  Ontogenesis of thyrotropin-releasing hormone in the human fetal pancreas. A combined radioimmunological and immunocytochemical study.

Authors:  P Leduque; S Aratan-Spire; P Czernichow; P M Dubois
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

2.  Evidence for high peptide alpha-amidating activity in the pancrease from neonatal rats.

Authors:  L Ouafik; P Giraud; P Salers; A Dutour; E Castanas; F Boudouresque; C Oliver
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

3.  Plasma levels of thyrotropin-releasing-hormone in various splanchnic, renal, suprarenal, and cerebral veins.

Authors:  I Vardarl; J M Wdowinski; J Hoevels; R Schmidt; U Schwedes; M Georgi; K H Usadel
Journal:  Klin Wochenschr       Date:  1987-02-02

4.  Evidence for pyroglutamyl peptidase I and prolyl endopeptidase activities in the rat insulinoma cell line RINm 5F: lack of relationship with TRH metabolism.

Authors:  P Salers; L H Ouafik; P Giraud; A Dutour; J Y Maltese; C Oliver
Journal:  Mol Cell Biochem       Date:  1991-07-24       Impact factor: 3.396

5.  Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.

Authors:  E Martino; H Seo; A Lernmark; S Refetoff
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

6.  Identification and localization of glucagon-related peptides in rat brain.

Authors:  H Tager; M Hohenboken; J Markese; R J Dinerstein
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

Review 7.  The gastrointestinal endocrine system.

Authors:  N S Track
Journal:  Can Med Assoc J       Date:  1980-02-09       Impact factor: 8.262

8.  TRH-like immunoreactivity in endocrine cells and neurons in the gastro-intestinal tract of the rat and guinea pig.

Authors:  Y Tsuruo; T Hökfelt; T J Visser; J R Kimmel; J C Brown; A Verhofstadt; J Walsh
Journal:  Cell Tissue Res       Date:  1988-08       Impact factor: 5.249

9.  Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.

Authors:  P Giraud; J Y Maltèse; F Boudouresque; P Salers; L Ouafik; M Renard; F Pelen; C Oliver
Journal:  Biol Trace Elem Res       Date:  1992 Jan-Mar       Impact factor: 3.738

10.  Presence of thyrotropin-releasing hormone in porcine and bovine retina.

Authors:  E Martino; M Nardi; G Vaudagna; S Simonetti; A Cilotti; A Pinchera
Journal:  Experientia       Date:  1980-05-15
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.