| Literature DB >> 3136924 |
Y Tsuruo1, T Hökfelt, T J Visser, J R Kimmel, J C Brown, A Verhofstadt, J Walsh.
Abstract
By use of the indirect immunofluorescence technique, the cellular localization of thyrotropin-releasing hormone (TRH) was studied in the gastrointestinal tract of rats and guinea pigs of different ages. TRH-like immunoreactivity (LI) was observed in many pancreatic islet cells of young rats and guinea pigs but only in single cells of 6-month-old rats. In aged guinea pigs, a reduction in the number of TRH-positive cells was evident; however, numerous strongly fluorescent cells were still present. In the guinea pig, TRH-LI was in addition observed in gastrin cells in the stomach. TRH-positive nerve fibers occurred in the myenteric plexus of the oesophagus, stomach and intestine of the rat, and in the muscle layers of the guinea pig. These results suggest a functional role of TRH both as hormone and neuroactive compound in various portions and sites of the gastro-intestinal tract of the rat and guinea pig.Entities:
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Year: 1988 PMID： 3136924 DOI： 10.1007/bf00222291
Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249