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Literature DB >> 9925531

Efflux pump-mediated quinolone resistance in Staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA.

J L Muñoz-Bellido¹, M Alonzo Manzanares, J A Martínez Andrés, M N Guttiérrez Zufiaurre, G Ortiz, M Segovia Hernández, J A García-Rodríguez.

Abstract

Fluoroquinolone efflux was studied in 47 Staphylococcus aureus clinical strains with MICs of ciprofloxacin (CFX) of < or = 2 micrograms/ml. Forty-three strains were wild type for gyrA, gyrB, and grlA quinolone resistance-determining regions and for norA and its promoter region. Forty of these strains (MICs of CFX, 0.1 to 0.2 microgram/ml) did not show efflux of fluoroquinolones. Three strains (MICs of CFX, 1 to 2 micrograms/ml) showed efflux. These results suggest that efflux can appear in S. aureus clinical strains in the absence of mutations in norA and its promoter.

Entities: Chemical Species

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Year: 1999 PMID： 9925531 PMCID： PMC89076

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.

Authors: S Sreedharan; M Oram; B Jensen; L R Peterson; L M Fisher
Journal: J Bacteriol Date: 1990-12 Impact factor: 3.490

2. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors: H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal: J Bacteriol Date: 1990-12 Impact factor: 3.490

3. Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.

Authors: T Takenouchi; F Tabata; Y Iwata; H Hanzawa; M Sugawara; S Ohya
Journal: Antimicrob Agents Chemother Date: 1996-08 Impact factor: 5.191

4. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.

Authors: E Y Ng; M Trucksis; D C Hooper
Journal: Antimicrob Agents Chemother Date: 1994-06 Impact factor: 5.191

5. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

Authors: L Ferrero; B Cameron; B Manse; D Lagneaux; J Crouzet; A Famechon; F Blanche
Journal: Mol Microbiol Date: 1994-08 Impact factor: 3.501

6. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.

Authors: H Ito; H Yoshida; M Bogaki-Shonai; T Niga; H Hattori; S Nakamura
Journal: Antimicrob Agents Chemother Date: 1994-09 Impact factor: 5.191

7. Inducible NorA-mediated multidrug resistance in Staphylococcus aureus.

Authors: G W Kaatz; S M Seo
Journal: Antimicrob Agents Chemother Date: 1995-12 Impact factor: 5.191

8. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

9. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus.

Authors: G W Kaatz; S M Seo; C A Ruble
Journal: Antimicrob Agents Chemother Date: 1993-05 Impact factor: 5.191

10. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus.

Authors: L Ferrero; B Cameron; J Crouzet
Journal: Antimicrob Agents Chemother Date: 1995-07 Impact factor: 5.191

18 in total

1. In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.

Authors: M Boos; S Mayer; A Fischer; K Köhrer; S Scheuring; P Heisig; J Verhoef; A C Fluit; F J Schmitz
Journal: Antimicrob Agents Chemother Date: 2001-03 Impact factor: 5.191

Review 2. Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria.

Authors: K Poole
Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

3. Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus.

Authors: Laura J V Piddock; Yu Fang Jin; Mark A Webber; Martin J Everett
Journal: Antimicrob Agents Chemother Date: 2002-07 Impact factor: 5.191

4. In vitro activities of six quinolones and mechanisms of resistance in Staphylococcus aureus and coagulase-negative staphylococci.

Authors: H J Linde; M Schmidt; E Fuchs; U Reischl; H H Niller; N Lehn
Journal: Antimicrob Agents Chemother Date: 2001-05 Impact factor: 5.191

5. Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853).

Authors: Steve Mullin; Nagraj Mani; Trudy H Grossman
Journal: Antimicrob Agents Chemother Date: 2004-11 Impact factor: 5.191

Review 6. Regulation of bacterial drug export systems.

Authors: Steve Grkovic; Melissa H Brown; Ronald A Skurray
Journal: Microbiol Mol Biol Rev Date: 2002-12 Impact factor: 11.056

7. Evolution of ciprofloxacin-resistant Staphylococcus aureus in in vitro pharmacokinetic environments.

Authors: Jeffrey J Campion; Patrick J McNamara; Martin E Evans
Journal: Antimicrob Agents Chemother Date: 2004-12 Impact factor: 5.191

8. Real-time PCR assay for detection of fluoroquinolone resistance associated with grlA mutations in Staphylococcus aureus.

Authors: Pascal Lapierre; Ann Huletsky; Véronique Fortin; François J Picard; Paul H Roy; Marc Ouellette; Michel G Bergeron
Journal: J Clin Microbiol Date: 2003-07 Impact factor: 5.948

Review 9. Efflux-mediated drug resistance in bacteria.

Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2004 Impact factor: 9.546

10. Association of norB overexpression and fluoroquinolone resistance in clinical isolates of Staphylococcus aureus from Korea.

Authors: Yee Gyung Kwak; Que Chi Truong-Bolduc; Hong Bin Kim; Kyoung-Ho Song; Eu Suk Kim; David C Hooper
Journal: J Antimicrob Chemother Date: 2013-08-08 Impact factor: 5.790