Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 New developments in understanding the etiology of Parkinson's disease and in its treatment.

Literature DB >> 9914234

New developments in understanding the etiology of Parkinson's disease and in its treatment.

A M Lozano¹, A E Lang, W D Hutchison, J O Dostrovsky.

Abstract

Important recent advances have been made in understanding the etiology and pathogenesis of Parkinson's disease, as well as in developing novel treatments. Two newly identified genes, alpha-synuclein and parkin, have been linked to parkinsonism. In addition, disturbances to the normal basal ganglia circuits in Parkinson's patients are being described at both anatomical and physiological levels. These developments provide a strong scientific basis for novel medical and surgical strategies to treat the profound motor disturbances in patients with Parkinson's disease.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9914234 DOI： 10.1016/s0959-4388(98)80122-0

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

Keyword Cloud
Cited

13 in total

1. Discovery of Potent and Selective A_2A Antagonists with Efficacy in Animal Models of Parkinson's Disease and Depression.

Authors: Sujay Basu; Dinesh A Barawkar; Vidya Ramdas; Minakshi Naykodi; Yogesh D Shejul; Meena Patel; Sachin Thorat; Anil Panmand; K Kashinath; Rajesh Bonagiri; Vandna Prasad; Ganesh Bhat; Azfar Quraishi; Sumit Chaudhary; Amol Magdum; Ashwinkumar V Meru; Indraneel Ghosh; Ravi K Bhamidipati; Amol A Raje; Vamsi L M Madgula; Siddhartha De; Sreekanth R Rouduri; Venkata P Palle; Anita Chugh; Narayanan Hariharan; Kasim A Mookhtiar
Journal: ACS Med Chem Lett Date: 2017-07-05 Impact factor: 4.345

2. Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism.

Authors: A Raz; E Vaadia; H Bergman
Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167

3. Beyond knockout rats: new insights into finer genome manipulation in rats.

Authors: Guanyi Huang; Chang Tong; Dhruv S Kumbhani; Charles Ashton; Hexin Yan; Qi-Long Ying
Journal: Cell Cycle Date: 2011-04-01 Impact factor: 4.534

4. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels.

Authors: B Liss; A Neu; J Roeper
Journal: J Neurosci Date: 1999-10-15 Impact factor: 6.167

New developments in understanding the etiology of Parkinson's disease and in its treatment.

1. Discovery of Potent and Selective A_2A Antagonists with Efficacy in Animal Models of Parkinson's Disease and Depression.

2. Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism.

3. Beyond knockout rats: new insights into finer genome manipulation in rats.

4. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels.

5. Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination.

6. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release.

7. Prediction of mild parkinsonism revealed by neural oscillatory changes and machine learning.

Review 8. Adenosine A(2A) Receptor Antagonists and Parkinson's Disease.

Review 9. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration.

Review 10. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.