Literature DB >> 9873504

Anti-AIDS agents. 33. Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues.

L Xie1, Y Takeuchi, L M Cosentino, K H Lee.   

Abstract

Four isomeric methyl substituted DCK analogues (2-5) were asymmetrically synthesized from different starting materials. 3-Methyl, 4-methyl, and 5-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (2-4) all were extremely potent against HIV-1 replication in H9 lymphocyte cells with EC50 and therapeutic index values of < 4.23 x 10(-7) microM and > 3.72 x 10(8), respectively, which are much better than those of DCK and AZT in this assay.

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Year:  1998        PMID： 9873504     DOI： 10.1016/s0960-894x(98)00367-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Cytotoxic activity of new acetoxycoumarin derivatives in cancer cell lines.

Authors:  Musiliyu A Musa; Veera L D Badisa; Lekan M Latinwo; John Cooperwood; Andre Sinclair; Ahkinyala Abdullah
Journal:  Anticancer Res       Date:  2011-06       Impact factor: 2.480

2.  In vitro cytotoxicity of benzopyranone derivatives with basic side chain against human lung cell lines.

Authors:  Musiliyu A Musa; Veera L D Badisa; Lekan M Latinwo; Caroline Waryoba; Ngozi Ugochukwu
Journal:  Anticancer Res       Date:  2010-11       Impact factor: 2.480

3.  Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.

Authors:  Hong-Shan Liu; Shi-Qing Xu; Ming Cheng; Ying Chen; Peng Xia; Keduo Qian; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-08-03       Impact factor: 2.823

4.  In-vitro antiproliferative activity of benzopyranone derivatives in comparison with standard chemotherapeutic drugs.

Authors:  Musiliyu A Musa; John S Cooperwood; M Omar F Khan; Taufiq Rahman
Journal:  Arch Pharm (Weinheim)       Date:  2010-11-29       Impact factor: 3.751

5.  Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines.

Authors:  Musiliyu A Musa; M Omar F Khan; John S Cooperwood
Journal:  Lett Drug Des Discov       Date:  2009-03       Impact factor: 1.150

6.  Synthesis, spectroscopic, dielectric, molecular docking and DFT studies of (3E)-3-(4-methylbenzylidene)-3,4-dihydro-2H-chromen-2-one: an anticancer agent.

Authors:  T Beena; L Sudha; A Nataraj; V Balachandran; D Kannan; M N Ponnuswamy
Journal:  Chem Cent J       Date:  2017-01-10       Impact factor: 4.215

Review 7.  Therapeutic potential of coumarins as antiviral agents.

Authors:  Mohd Zaheen Hassan; Hasnah Osman; Mohamed Ashraf Ali; Mohamed Jawed Ahsan
Journal:  Eur J Med Chem       Date:  2016-07-25       Impact factor: 6.514

Review 8.  Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease.

Authors:  Zhoupeng Li; Dehui Kong; Yongsheng Liu; Mingkai Li
Journal:  Genes Dis       Date:  2021-04-20

9.  Design, synthesis and antitumor activity of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives.

Authors:  Luhui Ren; Xue Du; Mengnan Hu; Chaoqun Yan; Taigang Liang; Qingshan Li
Journal:  Molecules       Date:  2013-04-08       Impact factor: 4.411
  9 in total

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