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Literature DB >> 20556210

Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines.

Musiliyu A Musa¹, M Omar F Khan, John S Cooperwood.

Abstract

The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 muM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.

Entities: CellLine Chemical Disease Gene Mutation Species

Year: 2009 PMID： 20556210 PMCID： PMC2885731 DOI： 10.2174/157018009787582624

Source DB: PubMed Journal: Lett Drug Des Discov ISSN： 1570-1808 Impact factor: 1.150

37 in total

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3 in total