| Literature DB >> 9871534 |
J P Edwards1, S J West, C L Pooley, K B Marschke, L J Farmer, T K Jones.
Abstract
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.Entities:
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Year: 1998 PMID： 9871534 DOI： 10.1016/s0960-894x(98)00107-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823