Literature DB >> 18007415

Synthesis and antitumor activity of 5-trifluoromethyl-2,4- dihydropyrazol-3-one nucleosides.

Ibrahim M Abdou1, Ayman M Saleh, Hussein F Zohdi.   

Abstract

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by (1)H and (13)C-NMR spectroscopy. Glucoside 3b shows an in vitro IC(50) value of 16.4 muM against proliferation of the human promyelotic leukemia (HL60) cell line.

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Year:  2004        PMID： 18007415      PMCID： PMC6147422          DOI： 10.3390/90300109

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  7 in total

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Journal:  J Med Chem       Date:  1997-08-01       Impact factor: 7.446

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Journal:  Chem Res Toxicol       Date:  2002-01       Impact factor: 3.739

3.  Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.

Authors:  Swarna A Gamage; Julie A Spicer; Gordon W Rewcastle; John Milton; Sukhjit Sohal; Wendy Dangerfield; Prakash Mistry; Nigel Vicker; Peter A Charlton; William A Denny
Journal:  J Med Chem       Date:  2002-01-31       Impact factor: 7.446

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Authors:  J P Edwards; R I Higuchi; D T Winn; C L Pooley; T R Caferro; L G Hamann; L Zhi; K B Marschke; M E Goldman; T K Jones
Journal:  Bioorg Med Chem Lett       Date:  1999-04-05       Impact factor: 2.823

5.  Synthesis, characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines.

Authors:  S Güniz Küçükgüzel; S Rollas; H Erdeniz; M Kiraz; A Cevdet Ekinci; A Vidin
Journal:  Eur J Med Chem       Date:  2000 Jul-Aug       Impact factor: 6.514

6.  New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones.

Authors:  K L Kees; J J Fitzgerald; K E Steiner; J F Mattes; B Mihan; T Tosi; D Mondoro; M L McCaleb
Journal:  J Med Chem       Date:  1996-09-27       Impact factor: 7.446

7.  New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.

Authors:  J P Edwards; S J West; C L Pooley; K B Marschke; L J Farmer; T K Jones
Journal:  Bioorg Med Chem Lett       Date:  1998-04-07       Impact factor: 2.823
  7 in total
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2.  Crystal structures of 3-fluoro-N-[2-(tri-fluoro-meth-yl)phen-yl]benzamide, 3-bromo-N-[2-(tri-fluoro-meth-yl)phen-yl]benzamide and 3-iodo-N-[2-(tri-fluoro-meth-yl)phen-yl]benzamide.

Authors:  P A Suchetan; E Suresha; S Naveen; N K Lokanath
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-05-17

3.  Structural analysis of 2-iodo-benzamide and 2-iodo-N-phenyl-benzamide.

Authors:  Keshab M Bairagi; Vipin B S Kumar; Subhrajyoti Bhandary; Katharigatta N Venugopala; Susanta K Nayak
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-07-20
  3 in total

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