| Literature DB >> 9871520 |
G Semple1, D M Ashworth, A R Batt, A J Baxter, D W Benzies, L H Elliot, D M Evans, R J Franklin, P Hudson, P D Jenkins, G R Pitt, D P Rooker, S Yamamoto, Y Isomura.
Abstract
Pyridone-based peptidomimetic inhibitors of recombinant human Interleukin-1 beta-converting enzyme (ICE, caspase-1) with an aminomethylene ketone activating group in the P1' position are described. Several analogues with sub-nanomolar Ki's versus ICE and improved aqueous solubility are reported.Entities:
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Year: 1998 PMID： 9871520 DOI： 10.1016/s0960-894x(98)00136-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823