Literature DB >> 9869588

Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.

G A McConkey1.   

Abstract

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.

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Year:  1999        PMID： 9869588      PMCID： PMC89043     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Synthesis of (-)-2-Fluoroshikimic Acid.

Authors:  Robert H. Rich; Paul A. Bartlett
Journal:  J Org Chem       Date:  1996-05-31       Impact factor: 4.354

Review 2.  Hemoglobin metabolism in the malaria parasite Plasmodium falciparum.

Authors:  S E Francis; D J Sullivan; D E Goldberg
Journal:  Annu Rev Microbiol       Date:  1997       Impact factor: 15.500

3.  The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.

Authors:  M J Rogers; E Cundliffe; T F McCutchan
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

Review 4.  Hemoglobin catabolism and iron utilization by malaria parasites.

Authors:  P J Rosenthal; S R Meshnick
Journal:  Mol Biochem Parasitol       Date:  1996-12-20       Impact factor: 1.759

5.  A plastid of probable green algal origin in Apicomplexan parasites.

Authors:  S Köhler; C F Delwiche; P W Denny; L G Tilney; P Webster; R J Wilson; J D Palmer; D S Roos
Journal:  Science       Date:  1997-03-07       Impact factor: 47.728

6.  Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth.

Authors:  G A McConkey; I Ittarat; S R Meshnick; T F McCutchan
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

7.  (6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway.

Authors:  G M Davies; K J Barrett-Bee; D A Jude; M Lehan; W W Nichols; P E Pinder; J L Thain; W J Watkins; R G Wilson
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

8.  Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate.

Authors:  S Bornemann; M K Ramjee; S Balasubramanian; C Abell; J R Coggins; D J Lowe; R N Thorneley
Journal:  J Biol Chem       Date:  1995-09-29       Impact factor: 5.157

9.  Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth.

Authors:  A A Divo; T G Geary; N L Davis; J B Jensen
Journal:  J Protozool       Date:  1985-02

10.  Mechanisms of sulfadoxine resistance in Plasmodium falciparum.

Authors:  A Dieckmann; A Jung
Journal:  Mol Biochem Parasitol       Date:  1986-05       Impact factor: 1.759
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  17 in total

1.  The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.

Authors:  Sheng Ye; Frank Von Delft; Alexei Brooun; Mark W Knuth; Ronald V Swanson; Duncan E McRee
Journal:  J Bacteriol       Date:  2003-07       Impact factor: 3.490

2.  Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements.

Authors:  Thomas A Richards; Joel B Dacks; Samantha A Campbell; Jeffrey L Blanchard; Peter G Foster; Rima McLeod; Craig W Roberts
Journal:  Eukaryot Cell       Date:  2006-09

3.  Structural basis for shikimate-binding specificity of Helicobacter pylori shikimate kinase.

Authors:  Wen-Chi Cheng; Yu-Ning Chang; Wen-Ching Wang
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

4.  Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway.

Authors:  Neetu Neetu; Madhusudhanarao Katiki; Aditya Dev; Stuti Gaur; Shailly Tomar; Pravindra Kumar
Journal:  J Bacteriol       Date:  2020-08-25       Impact factor: 3.490

5.  Molecular basis for the herbicide resistance of Roundup Ready crops.

Authors:  Todd Funke; Huijong Han; Martha L Healy-Fried; Markus Fischer; Ernst Schönbrunn
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-17       Impact factor: 11.205

6.  Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

Authors:  Sarmad N Mageed; Fraser Cunningham; Alvin Wei Hung; Hernani Leonardo Silvestre; Shijun Wen; Tom L Blundell; Chris Abell; Glenn A McConkey
Journal:  Antimicrob Agents Chemother       Date:  2014-07-21       Impact factor: 5.191

7.  Exploring the transcriptome of the malaria sporozoite stage.

Authors:  S H Kappe; M J Gardner; S M Brown; J Ross; K Matuschewski; J M Ribeiro; J H Adams; J Quackenbush; J Cho; D J Carucci; S L Hoffman; V Nussenzweig
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-07       Impact factor: 11.205

8.  Archaeal shikimate kinase, a new member of the GHMP-kinase family.

Authors:  M Daugherty; V Vonstein; R Overbeek; A Osterman
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

9.  Genome sequence of the human malaria parasite Plasmodium falciparum.

Authors:  Malcolm J Gardner; Neil Hall; Eula Fung; Owen White; Matthew Berriman; Richard W Hyman; Jane M Carlton; Arnab Pain; Karen E Nelson; Sharen Bowman; Ian T Paulsen; Keith James; Jonathan A Eisen; Kim Rutherford; Steven L Salzberg; Alister Craig; Sue Kyes; Man-Suen Chan; Vishvanath Nene; Shamira J Shallom; Bernard Suh; Jeremy Peterson; Sam Angiuoli; Mihaela Pertea; Jonathan Allen; Jeremy Selengut; Daniel Haft; Michael W Mather; Akhil B Vaidya; David M A Martin; Alan H Fairlamb; Martin J Fraunholz; David S Roos; Stuart A Ralph; Geoffrey I McFadden; Leda M Cummings; G Mani Subramanian; Chris Mungall; J Craig Venter; Daniel J Carucci; Stephen L Hoffman; Chris Newbold; Ronald W Davis; Claire M Fraser; Bart Barrell
Journal:  Nature       Date:  2002-10-03       Impact factor: 49.962

10.  Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain.

Authors:  Ivan G Shabalin; Artyom Gritsunov; Jing Hou; Joanna Sławek; Charles D Miks; David R Cooper; Wladek Minor; Dinesh Christendat
Journal:  FEBS J       Date:  2019-12-26       Impact factor: 5.542
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