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Literature DB >> 9517961

The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.

M J Rogers¹, E Cundliffe, T F McCutchan.

Abstract

The antibiotic micrococcin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1998 PMID： 9517961 PMCID： PMC105527

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite.

Authors: M J Rogers; Y V Bukhman; T F McCutchan; D E Draper
Journal: RNA Date: 1997-08 Impact factor: 4.942

2. The binding of thiostrepton to 23S ribosomal RNA.

Authors: J Thompson; E Cundliffe
Journal: Biochimie Date: 1991 Jul-Aug Impact factor: 4.079

3. Plastid in human parasites.

Authors: G I McFadden; M E Reith; J Munholland; N Lang-Unnasch
Journal: Nature Date: 1996-06-06 Impact factor: 49.962

4. Thiostrepton: a ribosomal inhibitor of translocation.

Authors: S Pestka
Journal: Biochem Biophys Res Commun Date: 1970-08-11 Impact factor: 3.575

5. Effects of antibiotics on Plasmodium falciparum in vitro.

Authors: T G Geary; J B Jensen
Journal: Am J Trop Med Hyg Date: 1983-03 Impact factor: 2.345

Review 6. Falciparum malaria: the urgent need for safe and effective drugs.

Authors: K H Rieckmann
Journal: Annu Rev Med Date: 1983 Impact factor: 13.739

7. A plastid of probable green algal origin in Apicomplexan parasites.

Authors: S Köhler; C F Delwiche; P W Denny; L G Tilney; P Webster; R J Wilson; J D Palmer; D S Roos
Journal: Science Date: 1997-03-07 Impact factor: 47.728

8. Concerning the mode of action of micrococcin upon bacterial protein synthesis.

Authors: E Cundliffe; J Thompson
Journal: Eur J Biochem Date: 1981-08

9. Secretory transport in Plasmodium.

Authors: H G Elmendorf; K Haldar
Journal: Parasitol Today Date: 1993-03

10. Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture.

Authors: A A Divo; T G Geary; J B Jensen
Journal: Antimicrob Agents Chemother Date: 1985-01 Impact factor: 5.191

18 in total

1. The macrocyclic peptide antibiotic micrococcin P(1) is secreted by the food-borne bacterium Staphylococcus equorum WS 2733 and inhibits Listeria monocytogenes on soft cheese.

Authors: M C Carnio; A Höltzel; M Rudolf; T Henle; G Jung; S Scherer
Journal: Appl Environ Microbiol Date: 2000-06 Impact factor: 4.792

The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.

1. Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite.

2. The binding of thiostrepton to 23S ribosomal RNA.

3. Plastid in human parasites.

4. Thiostrepton: a ribosomal inhibitor of translocation.

5. Effects of antibiotics on Plasmodium falciparum in vitro.

Review 6. Falciparum malaria: the urgent need for safe and effective drugs.

7. A plastid of probable green algal origin in Apicomplexan parasites.

8. Concerning the mode of action of micrococcin upon bacterial protein synthesis.

9. Secretory transport in Plasmodium.

10. Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture.

1. The macrocyclic peptide antibiotic micrococcin P(1) is secreted by the food-borne bacterium Staphylococcus equorum WS 2733 and inhibits Listeria monocytogenes on soft cheese.

2. Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.

3. Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.

4. Characterization of a novel plasmid-borne thiopeptide gene cluster in Staphylococcus epidermidis strain 115.

5. Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.

Review 6. Elucidating and engineering thiopeptide biosynthesis.

7. A plastid segregation defect in the protozoan parasite Toxoplasma gondii.

8. Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

9. In vitro antimalarial activity of novel semisynthetic nocathiacin I antibiotics.

10. Diversity of antibiotic-active bacteria associated with the brown alga Laminaria saccharina from the Baltic Sea.