| Literature DB >> 12368864 |
Malcolm J Gardner1, Neil Hall, Eula Fung, Owen White, Matthew Berriman, Richard W Hyman, Jane M Carlton, Arnab Pain, Karen E Nelson, Sharen Bowman, Ian T Paulsen, Keith James, Jonathan A Eisen, Kim Rutherford, Steven L Salzberg, Alister Craig, Sue Kyes, Man-Suen Chan, Vishvanath Nene, Shamira J Shallom, Bernard Suh, Jeremy Peterson, Sam Angiuoli, Mihaela Pertea, Jonathan Allen, Jeremy Selengut, Daniel Haft, Michael W Mather, Akhil B Vaidya, David M A Martin, Alan H Fairlamb, Martin J Fraunholz, David S Roos, Stuart A Ralph, Geoffrey I McFadden, Leda M Cummings, G Mani Subramanian, Chris Mungall, J Craig Venter, Daniel J Carucci, Stephen L Hoffman, Chris Newbold, Ronald W Davis, Claire M Fraser, Bart Barrell.
Abstract
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.Entities:
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Year: 2002 PMID： 12368864 PMCID： PMC3836256 DOI： 10.1038/nature01097
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962