Literature DB >> 9868152

Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

J A Beutler1, R H Shoemaker, T Johnson, M R Boyd.   

Abstract

Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.

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Year:  1998        PMID： 9868152     DOI： 10.1021/np980208m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  35 in total

1.  Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

Authors:  Natalie C Ulrich; John G Kodet; Nolan R Mente; Craig H Kuder; John A Beutler; Raymond J Hohl; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2010-01-04       Impact factor: 3.641

2.  Fluorescent schweinfurthin B and F analogs with anti-proliferative activity.

Authors:  Joseph J Topczewski; Craig H Kuder; Jeffrey D Neighbors; Raymond J Hohl; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2010-07-29       Impact factor: 3.641

3.  Synthesis of indole analogues of the natural schweinfurthins.

Authors:  John G Kodet; David F Wiemer
Journal:  J Org Chem       Date:  2013-09-05       Impact factor: 4.354

4.  Synthesis and structure activity relationships of schweinfurthin indoles.

Authors:  John G Kodet; John A Beutler; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2014-03-06       Impact factor: 3.641

5.  Natural products reveal cancer cell dependence on oxysterol-binding proteins.

Authors:  Anthony W G Burgett; Thomas B Poulsen; Kittikhun Wangkanont; D Ryan Anderson; Chikako Kikuchi; Kousei Shimada; Shuichi Okubo; Kevin C Fortner; Yoshihiro Mimaki; Minpei Kuroda; Jason P Murphy; David J Schwalb; Eugene C Petrella; Ivan Cornella-Taracido; Markus Schirle; John A Tallarico; Matthew D Shair
Journal:  Nat Chem Biol       Date:  2011-08-07       Impact factor: 15.040

6.  Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor.

Authors:  Tiphaine Péresse; David Kovacs; Mélody Subra; Joëlle Bigay; Meng-Chen Tsai; Joël Polidori; Romain Gautier; Sandy Desrat; Lucile Fleuriot; Delphine Debayle; Marc Litaudon; Van-Cuong Pham; Jérôme Bignon; Bruno Antonny; Fanny Roussi; Bruno Mesmin
Journal:  J Biol Chem       Date:  2020-02-19       Impact factor: 5.157

7.  Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil.

Authors:  Ryan M Sheehy; Craig H Kuder; Zoe Bachman; Raymond J Hohl
Journal:  Cancer Biol Ther       Date:  2015-06-05       Impact factor: 4.742

8.  Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking.

Authors:  Xingfeng Bao; Wanjun Zheng; Naoko Hata Sugi; Kishan L Agarwala; Qunli Xu; Zichun Wang; Karen Tendyke; Winnie Lee; Lana Parent; Wei Li; Hongsheng Cheng; Yongchun Shen; Noel Taylor; Zoltan Dezso; Hong Du; Yoshihiko Kotake; Nanding Zhao; John Wang; Maarten Postema; Mary Woodall-Jappe; Yasutaka Takase; Toshimitsu Uenaka; David G I Kingston; Kenichi Nomoto
Journal:  Cancer Biol Ther       Date:  2015-03-02       Impact factor: 4.742

9.  Synthesis of amide isosteres of schweinfurthin-based stilbenes.

Authors:  David P Stockdale; John A Beutler; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2017-08-09       Impact factor: 3.641

10.  Schweinfurthins I and J from Macaranga schweinfurthii.

Authors:  Paul Klausmeyer; Que N Van; Johnson Jato; Thomas G McCloud; John A Beutler
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050
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