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Literature DB >> 20116262

Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

Natalie C Ulrich¹, John G Kodet, Nolan R Mente, Craig H Kuder, John A Beutler, Raymond J Hohl, David F Wiemer.

Abstract

The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 20116262 PMCID： PMC5520629 DOI： 10.1016/j.bmc.2009.12.063

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

15 in total

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Authors: J A Beutler; R H Shoemaker; T Johnson; M R Boyd
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5. An information-intensive approach to the molecular pharmacology of cancer.

Authors: J N Weinstein; T G Myers; P M O'Connor; S H Friend; A J Fornace; K W Kohn; T Fojo; S E Bates; L V Rubinstein; N L Anderson; J K Buolamwini; W W van Osdol; A P Monks; D A Scudiero; E A Sausville; D W Zaharevitz; B Bunow; V N Viswanadhan; G S Johnson; R E Wittes; K D Paull
Journal: Science Date: 1997-01-17 Impact factor: 47.728

6. Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

Authors: Brent J Yoder; Shugeng Cao; Andrew Norris; James S Miller; Fidy Ratovoson; Jeremi Razafitsalama; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
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7. Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

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Authors: Joseph J Topczewski; Jeffrey D Neighbors; David F Wiemer
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9. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.

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16 in total

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3. Synthesis and structure activity relationships of schweinfurthin indoles.

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Journal: Bioorg Med Chem Date: 2014-03-06 Impact factor: 3.641

4. Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

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Journal: Oncoimmunology Date: 2018-11-11 Impact factor: 8.110

5. Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

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Journal: Bioorg Med Chem Date: 2011-10-19 Impact factor: 3.641

6. First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.

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7. Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.

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