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Literature DB >> 20000454

Schweinfurthins I and J from Macaranga schweinfurthii.

Paul Klausmeyer¹, Que N Van, Johnson Jato, Thomas G McCloud, John A Beutler.

Abstract

Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20000454 PMCID： PMC2846236 DOI： 10.1021/np9006348

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

4 in total

1. Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

Authors: J A Beutler; R H Shoemaker; T Johnson; M R Boyd
Journal: J Nat Prod Date: 1998-12 Impact factor: 4.050

Review 2. The NCI60 human tumour cell line anticancer drug screen.

Authors: Robert H Shoemaker
Journal: Nat Rev Cancer Date: 2006-10 Impact factor: 60.716

3. Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

Authors: Brent J Yoder; Shugeng Cao; Andrew Norris; James S Miller; Fidy Ratovoson; Jeremi Razafitsalama; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal: J Nat Prod Date: 2007-02-28 Impact factor: 4.050

4. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

Authors: D A Scudiero; R H Shoemaker; K D Paull; A Monks; S Tierney; T H Nofziger; M J Currens; D Seniff; M R Boyd
Journal: Cancer Res Date: 1988-09-01 Impact factor: 12.701

4 in total

8 in total

1. Synthesis and structure activity relationships of schweinfurthin indoles.

Authors: John G Kodet; John A Beutler; David F Wiemer
Journal: Bioorg Med Chem Date: 2014-03-06 Impact factor: 3.641

2. Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor.

Authors: Tiphaine Péresse; David Kovacs; Mélody Subra; Joëlle Bigay; Meng-Chen Tsai; Joël Polidori; Romain Gautier; Sandy Desrat; Lucile Fleuriot; Delphine Debayle; Marc Litaudon; Van-Cuong Pham; Jérôme Bignon; Bruno Antonny; Fanny Roussi; Bruno Mesmin
Journal: J Biol Chem Date: 2020-02-19 Impact factor: 5.157

3. Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Authors: Tanja Grkovic; Jason R Evans; Rhone K Akee; Liang Guo; Myrtle Davis; Johnson Jato; Paul G Grothaus; Michelle Ahalt-Gottholm; Melinda Hollingshead; Jerry M Collins; David J Newman; Barry R O'Keefe
Journal: Bioorg Med Chem Lett Date: 2018-12-10 Impact factor: 2.823

Schweinfurthins I and J from Macaranga schweinfurthii.

1. Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

Review 2. The NCI60 human tumour cell line anticancer drug screen.

3. Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

4. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

1. Synthesis and structure activity relationships of schweinfurthin indoles.

2. Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor.

3. Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

4. Synthesis of amide isosteres of schweinfurthin-based stilbenes.

5. Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists.

6. RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins.

Review 7. Schweinfurthins A-Q: isolation, synthesis, and biochemical properties.

8. Schweinfurthin induces ICD without ER stress and caspase activation.