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Literature DB >> 9835532

An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression.

Abstract

The ampD and ampE genes of Pseudomonas aeruginosa PAO1 were cloned and characterized. These genes are transcribed in the same orientation and form an operon. The deduced polypeptide of P. aeruginosa ampD exhibited more than 60% similarity to the AmpD proteins of enterobacteria and Haemophilus influenzae. The ampD product transcomplemented Escherichia coli ampD mutants to wild-type beta-lactamase expression.

Entities: Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9835532 PMCID： PMC106040

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

28 in total

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17 in total

1. Inactivation of the ampDE operon increases transcription of algD and affects morphology and encystment of Azotobacter vinelandii.

Authors: C Núñez; S Moreno; L Cárdenas; G Soberón-Chávez; G Espín
Journal: J Bacteriol Date: 2000-09 Impact factor: 3.490

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Authors: Ming Ni; Dongshen Zhang; Junying Qi
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Authors: Amber J Schmidtke; Nancy D Hanson
Journal: Antimicrob Agents Chemother Date: 2006-06 Impact factor: 5.191

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Authors: Daniel J Wolter; Amber J Schmidtke; Nancy D Hanson; Philip D Lister
Journal: Antimicrob Agents Chemother Date: 2007-05-21 Impact factor: 5.191

5. Inactivation of the ampD gene in Pseudomonas aeruginosa leads to moderate-basal-level and hyperinducible AmpC beta-lactamase expression.

Authors: T Y Langaee; L Gagnon; A Huletsky
Journal: Antimicrob Agents Chemother Date: 2000-03 Impact factor: 5.191

6. Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level beta-lactam resistance involves three AmpD homologues.

Authors: Carlos Juan; Bartolomé Moyá; José L Pérez; Antonio Oliver
Journal: Antimicrob Agents Chemother Date: 2006-05 Impact factor: 5.191

7. Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains.

Authors: Carlos Juan; María D Maciá; Olivia Gutiérrez; Carmen Vidal; José L Pérez; Antonio Oliver
Journal: Antimicrob Agents Chemother Date: 2005-11 Impact factor: 5.191

8. AmpD is required for regulation of expression of NmcA, a carbapenem-hydrolyzing beta-lactamase of Enterobacter cloacae.

Authors: T Naas; S Massuard; F Garnier; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2001-10 Impact factor: 5.191

9. Structural and functional characterization of Pseudomonas aeruginosa global regulator AmpR.

Authors: Olivier Caille; Diansy Zincke; Massimo Merighi; Deepak Balasubramanian; Hansi Kumari; Kok-Fai Kong; Eugenia Silva-Herzog; Giri Narasimhan; Lisa Schneper; Stephen Lory; Kalai Mathee
Journal: J Bacteriol Date: 2014-09-02 Impact factor: 3.490

10. Identification of novel genes responsible for overexpression of ampC in Pseudomonas aeruginosa PAO1.

Authors: Yuko Tsutsumi; Haruyoshi Tomita; Koichi Tanimoto
Journal: Antimicrob Agents Chemother Date: 2013-09-16 Impact factor: 5.191