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Literature DB >> 15934297

Analysis of AmpC beta-lactamase gene in Pseudomonas aeruginosa .

Abstract

The gene and the amino acid sequence of the structural and regulatory region of the Pseudomonas aeruginosa with different resistance patterns were analyzed. Six strains with different resistance patterns were selected and the AmpC beta-lactamase was identified. The objective gene fragment was amplified by colonies PCR. The sequences of the PCR-products were analyzed. The DNA sequence of the structural gene ampC and the regulatory genes ampR, ampD and ampE was detected. The 6 strains and the wild-type Pseudomonas aeruginosa are highly homogeneous in structural and regulatory region. Some new mutant points were found.

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Year: 2005 PMID： 15934297 DOI： 10.1007/BF02831375

Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN： 1672-0733

10 in total

1. Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.

Authors: J M Lodge; S D Minchin; L J Piddock; S J Busby
Journal: Biochem J Date: 1990-12-15 Impact factor: 3.857

2. Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

Authors: J I Campbell; O Ciofu; N Høiby
Journal: Antimicrob Agents Chemother Date: 1997-06 Impact factor: 5.191

Review 3. Microbial resistance to newer generation beta-lactam antibiotics: clinical and laboratory implications.

Authors: C C Sanders; W E Sanders
Journal: J Infect Dis Date: 1985-03 Impact factor: 5.226

4. Inactivation of the ampD gene in Pseudomonas aeruginosa leads to moderate-basal-level and hyperinducible AmpC beta-lactamase expression.

Authors: T Y Langaee; L Gagnon; A Huletsky
Journal: Antimicrob Agents Chemother Date: 2000-03 Impact factor: 5.191

5. DNA sequence differences of ampD mutants of Citrobacter freundii.

Authors: P Stapleton; K Shannon; I Phillips
Journal: Antimicrob Agents Chemother Date: 1995-11 Impact factor: 5.191

6. Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center.

Authors: P E Coudron; E S Moland; K S Thomson
Journal: J Clin Microbiol Date: 2000-05 Impact factor: 5.948

1 in total

1. Role of MexA-MexB-OprM efflux pump system in chronic Pseudomonas aeruginosa pulmonary infection in mice.

Authors: Fengyun Gong; Weili Zhan; Lili Wang; Ying Song; Mingyou Xing; Jianxin Song
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2012-08-11

1 in total

Analysis of AmpC beta-lactamase gene in Pseudomonas aeruginosa .

1. Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.

2. Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

Review 3. Microbial resistance to newer generation beta-lactam antibiotics: clinical and laboratory implications.

4. Inactivation of the ampD gene in Pseudomonas aeruginosa leads to moderate-basal-level and hyperinducible AmpC beta-lactamase expression.

5. DNA sequence differences of ampD mutants of Citrobacter freundii.

6. Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center.

7. Sequencing and analysis of four new Enterobacter ampD Alleles.

8. An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression.

9. Sequences of wild-type and mutant ampD genes of Citrobacter freundii and Enterobacter cloacae.

10. Sequence elements determining ampC promoter strength in E. coli.

1. Role of MexA-MexB-OprM efflux pump system in chronic Pseudomonas aeruginosa pulmonary infection in mice.