| Literature DB >> 9824511 |
S Ishizaka1, M Kimoto, S Kanda, S Saito.
Abstract
The latent form of transforming growth factor-beta (TGF-beta) in human milk and platelets was converted to the active form when conscious, pylorus-ligated mice were given human milk and platelets by intragastric intubation. Oral administration of TGF-beta exerted enhancing effects on the natural killer (NK)-cell activities in spleen and liver. Augmentation of NK-cell activities in spleen was observed for 7 days after oral administration of TGF-beta. TGF-beta at concentrations of 5 and 20 ng produced the greatest augmentation of NK-cell activities in spleen. However, NK-cell activities in spleen were unaffected when TGF-beta was given intravenously. Interleukin (IL)-12 production in spleen was enhanced by oral administration of TGF-beta, but not by intravenous administration of TGF-beta. These findings suggest that large amounts of TGF-beta in human milk are involved in early antiviral protection through the augmentation of NK-cell activities.Entities:
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Year: 1998 PMID： 9824511 PMCID： PMC1364414 DOI： 10.1046/j.1365-2567.1998.00652.x
Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397