Literature DB >> 2447091

Human transforming growth factor beta.alpha 2-macroglobulin complex is a latent form of transforming growth factor beta.

S S Huang1, P O'Grady, J S Huang.   

Abstract

125I-Labeled human platelet-derived transforming growth factor beta (125I-TGF-beta) and human alpha 2-macroglobulin (alpha 2M) formed a complex as demonstrated by 5% native polyacrylamide gel electrophoresis. The 125I-TGF-beta.alpha 2M complex migrated at a position identical to that of the fast migrating form of alpha 2M. Most of the 125I-TGF-beta.alpha 2M complex could be dissociated by acid or urea treatment. When 125I-TGF-beta was incubated with serum, the high molecular weight form of 125I-TGF-beta could be immunoprecipitated by anti-human alpha 2M anti-sera as demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. alpha 2M purified from platelet-rich plasma also showed the latent transforming growth factor activity and immunoreactivity of TGF-beta. These results suggest that TGF-beta.alpha 2M complex is a latent form of TGF-beta.

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Year:  1988        PMID： 2447091

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  32 in total

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2.  Gene regulation networks related to neural differentiation of hESC.

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3.  Blood serum characteristics of newborn pigs: comparison of unaffected pigs with pigs belonging to five mortality groups.

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4.  Production of autostimulatory growth factors by the human carcinoma line, RPMI 2650.

Authors:  B M Carey; M Dooley; R Weedle; M Clynes
Journal:  In Vitro Cell Dev Biol       Date:  1993-02

5.  Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

Authors:  M G Bachem; D Meyer; R Melchior; K M Sell; A M Gressner
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

6.  Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strength in guinea pig dermal wounds healing by secondary intent.

Authors:  G A Ksander; Y Ogawa; G H Chu; H McMullin; J S Rosenblatt; J M McPherson
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Review 7.  Agonists and Antagonists of TGF-β Family Ligands.

Authors:  Chenbei Chang
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-08-01       Impact factor: 10.005

8.  Augmentation of natural killer cell activity in mice by oral administration of transforming growth factor-beta.

Authors:  S Ishizaka; M Kimoto; S Kanda; S Saito
Journal:  Immunology       Date:  1998-11       Impact factor: 7.397

9.  Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.

Authors:  K P Crookston; D J Webb; J Lamarre; S L Gonias
Journal:  Biochem J       Date:  1993-07-15       Impact factor: 3.857

Review 10.  An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective.

Authors:  C Yan Cheng; Dolores D Mruk
Journal:  Crit Rev Biochem Mol Biol       Date:  2009 Sep-Oct       Impact factor: 8.250
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