Literature DB >> 2788703

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

R L Coffman1, D A Lebman, B Shrader.   

Abstract

The addition of TGF-beta to cultures of LPS-stimulated murine B cells causes a approximately 10-fold enhancement of IgA production, yet causes a 10-fold decrease in total Ig production. IL-2 and, to a lesser extent, IL-5 synergize with TGF-beta to further enhance IgA production and partially reverse the inhibition of total Ig production. IgA constitutes only approximately 0.1% of total Ig in LPS-stimulated cultures, but that percentage rises to 15-25% in cultures to which TGF-beta and IL-2 are added. TGF-beta induces a substantial increase in IgA production from sIgA- B cells but inhibits IgA production by sIgA+ cells. This finding suggests that TGF-beta acts as an isotype-specific switch factor for IgA.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2788703      PMCID： PMC2189449          DOI： 10.1084/jem.170.3.1039

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

1.  BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.

Authors:  H J Ristow
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

2.  The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations.

Authors:  D A Lebman; R L Coffman
Journal:  J Immunol       Date:  1988-09-15       Impact factor: 5.422

Review 3.  Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response.

Authors:  J Mestecky; J R McGhee
Journal:  Adv Immunol       Date:  1987       Impact factor: 3.543

4.  Expression and secretion of type beta transforming growth factor by activated human macrophages.

Authors:  R K Assoian; B E Fleurdelys; H C Stevenson; P J Miller; D K Madtes; E W Raines; R Ross; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

5.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

6.  A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

Authors:  R L Coffman; J Carty
Journal:  J Immunol       Date:  1986-02-01       Impact factor: 5.422

7.  Transforming growth factor-beta: biological function and chemical structure.

Authors:  M B Sporn; A B Roberts; L M Wakefield; R K Assoian
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

8.  Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Authors:  J H Kehrl; A B Roberts; L M Wakefield; S Jakowlew; M B Sporn; A S Fauci
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422

9.  Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

Authors:  T Espevik; I S Figari; M R Shalaby; G A Lackides; G D Lewis; H M Shepard; M A Palladino
Journal:  J Exp Med       Date:  1987-08-01       Impact factor: 14.307

10.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors:  J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
View more
  135 in total

1.  Active suppression in orally tolerized rats coincides with in situ transforming growth factor-beta (TGF-beta) expression in the draining lymph nodes.

Authors:  B S Lundin; M R Karlsson; L A Svensson; L A Hanson; U I Dahlgren; E Telemo
Journal:  Clin Exp Immunol       Date:  1999-04       Impact factor: 4.330

Review 2.  Probiotics and immune response.

Authors:  Stephanie Blum; Dirk Haller; Andrea Pfeifer; Eduardo J Schiffrin
Journal:  Clin Rev Allergy Immunol       Date:  2002-06       Impact factor: 8.667

3.  Increased transforming growth factor-beta (TGF-beta)-secreting T cells and IgA anti-cardiolipin antibody levels during acute stage of childhood Henoch-Schönlein purpura.

Authors:  Y H Yang; M T Huang; S C Lin; Y T Lin; M J Tsai; B L Chiang
Journal:  Clin Exp Immunol       Date:  2000-11       Impact factor: 4.330

Review 4.  Role of the innate immune system in the development of chronic colitis.

Authors:  Takanori Kanai; Ryoichi Ilyama; Takahiro Ishikura; Koji Uraushihara; Teruji Totsuka; Motomi Yamazaki; Tetsuya Nakamuma; Mamoru Watanabe
Journal:  J Gastroenterol       Date:  2002-11       Impact factor: 7.527

5.  Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis.

Authors:  G Rostoker; H Terzidis; M Petit-Phar; D Meillet; P Lang; J M Dubert; G Lagrue; B Weil
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330

Review 6.  Divide and conquer: the importance of cell division in regulating B-cell responses.

Authors:  Stuart G Tangye; Philip D Hodgkin
Journal:  Immunology       Date:  2004-08       Impact factor: 7.397

Review 7.  The role of secretory antibodies in infection immunity.

Authors:  Richard A Strugnell; Odilia L C Wijburg
Journal:  Nat Rev Microbiol       Date:  2010-08-09       Impact factor: 60.633

Review 8.  TGF-beta: problems and prospects.

Authors:  M B Sporn; A B Roberts
Journal:  Cell Regul       Date:  1990-11

Review 9.  Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases.

Authors:  Charles B Smarr; Paul J Bryce; Stephen D Miller
Journal:  Crit Rev Immunol       Date:  2013       Impact factor: 2.214

10.  Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report.

Authors:  Ivana Kawikova; Bart P X Grady; Zuzana Tobiasova; Yan Zhang; Aristo Vojdani; Liliya Katsovich; Brian J Richmand; Tae Won Park; Alfred L M Bothwell; James F Leckman
Journal:  Biol Psychiatry       Date:  2009-12-14       Impact factor: 13.382
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.