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Literature DB >> 9811878

The three yeast A kinases have specific signaling functions in pseudohyphal growth.

Abstract

The three yeast A kinase catalytic subunit isoforms are redundant for viability. We demonstrate that they have dramatically different roles in pseudohyphal development: Tpk2 is essential, whereas Tpk3 inhibits. Tpk1 has no discernible effect. Two-hybrid analysis identified the transcription factor Sfl1 as a protein that interacts specifically with Tpk2, but not Tpk1 or Tpk3. Deletion of SFL1 enhances pseudohyphal and invasive growth. Flo11, a cell surface flocculin required for pseudohyphal development, is transcriptionally regulated by Tpk2 and Sfl1. Genetic evidence indicates that Tpk2 acts upstream of Sfl1 in the regulation of Flo11.

Entities: Gene Species

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Year: 1998 PMID： 9811878 PMCID： PMC24897 DOI： 10.1073/pnas.95.23.13783

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1.

Authors: J R Cherry; T R Johnson; C Dollard; J R Shuster; C L Denis
Journal: Cell Date: 1989-02-10 Impact factor: 41.582

2. Combinatorial control required for the specificity of yeast MAPK signaling.

Authors: H D Madhani; G R Fink
Journal: Science Date: 1997-02-28 Impact factor: 47.728

Review 3. Evolutionary origins and maintenance of redundant gene expression during metazoan development.

Authors: J Cooke; M A Nowak; M Boerlijst; J Maynard-Smith
Journal: Trends Genet Date: 1997-09 Impact factor: 11.639

4. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.

Authors: T Toda; S Cameron; P Sass; M Zoller; M Wigler
Journal: Cell Date: 1987-07-17 Impact factor: 41.582

5. Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.

Authors: M Grenson; M Mousset; J M Wiame; J Bechet
Journal: Biochim Biophys Acta Date: 1966-10-31

6. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae.

Authors: W S Lo; A M Dranginis
Journal: Mol Biol Cell Date: 1998-01 Impact factor: 4.138

7. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

Authors: P James; J Halladay; E A Craig
Journal: Genetics Date: 1996-12 Impact factor: 4.562

8. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.

Authors: H D Madhani; C A Styles; G R Fink
Journal: Cell Date: 1997-11-28 Impact factor: 41.582

9. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae.

Authors: S Cameron; L Levin; M Zoller; M Wigler
Journal: Cell Date: 1988-05-20 Impact factor: 41.582

10. Trimerization of a yeast transcriptional activator via a coiled-coil motif.

Authors: P K Sorger; H C Nelson
Journal: Cell Date: 1989-12-01 Impact factor: 41.582

160 in total

1. The yeast ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response.

Authors: A Stanhill; N Schick; D Engelberg
Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272

2. A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating.

Authors: B Guo; C A Styles; Q Feng; G R Fink
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

3. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.

Authors: M C Lorenz; X Pan; T Harashima; M E Cardenas; Y Xue; J P Hirsch; J Heitman
Journal: Genetics Date: 2000-02 Impact factor: 4.562

The three yeast A kinases have specific signaling functions in pseudohyphal growth.

1. Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1.

2. Combinatorial control required for the specificity of yeast MAPK signaling.

Review 3. Evolutionary origins and maintenance of redundant gene expression during metazoan development.

4. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.

5. Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.

6. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae.

7. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

8. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.

9. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae.

10. Trimerization of a yeast transcriptional activator via a coiled-coil motif.

1. The yeast ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response.

2. A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating.

3. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.

4. Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth.

5. Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

6. Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase.

7. Candida albicans Sfl1 suppresses flocculation and filamentation.

8. Roles of Candida albicans Sfl1 in hyphal development.

9. Amino acid starvation and Gcn4p regulate adhesive growth and FLO11 gene expression in Saccharomyces cerevisiae.

10. Filamentation Regulatory Pathways Control Adhesion-Dependent Surface Responses in Yeast.