Literature DB >> 2686840

Trimerization of a yeast transcriptional activator via a coiled-coil motif.

P K Sorger1, H C Nelson.   

Abstract

The transcriptional induction of heat shock genes is mediated by the heat shock transcription factor (HSF). We have investigated the oligomerization state of HSF from S. cerevisiae and find that it forms a trimer in solution and when bound to DNA. Trimerization is mediated by a region of HSF that, like the leucine zipper, is characterized by the occurrence of hydrophobic amino acids every 7 residues. We propose that it forms a three-stranded coiled coil.

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Year:  1989        PMID： 2686840     DOI： 10.1016/0092-8674(89)90604-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  137 in total

1.  Cell cycle-dependent binding of yeast heat shock factor to nucleosomes.

Authors:  C B Venturi; A M Erkine; D S Gross
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  Trimeric structure for an essential protein in L1 retrotransposition.

Authors:  Sandra L Martin; Dan Branciforte; David Keller; David L Bain
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-13       Impact factor: 11.205

Review 3.  Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Authors:  Daniel W Neef; Alex M Jaeger; Dennis J Thiele
Journal:  Nat Rev Drug Discov       Date:  2011-12-01       Impact factor: 84.694

Review 4.  [Molecular cell biology of the heat stress response. II].

Authors:  L Nover
Journal:  Naturwissenschaften       Date:  1990-08

5.  Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.

Authors:  K T Tamai; X Liu; P Silar; T Sosinowski; D J Thiele
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

6.  Functional analysis of HSF4 mutations found in patients with autosomal recessive congenital cataracts.

Authors:  Kate Merath; Adam Ronchetti; Duska J Sidjanin
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-10-11       Impact factor: 4.799

7.  Phosphorylation of the yeast heat shock transcription factor is implicated in gene-specific activation dependent on the architecture of the heat shock element.

Authors:  Naoya Hashikawa; Hiroshi Sakurai
Journal:  Mol Cell Biol       Date:  2004-05       Impact factor: 4.272

8.  Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells.

Authors:  S P Murphy; J J Gorzowski; K D Sarge; B Phillips
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

9.  Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition.

Authors:  J T Westwood; C Wu
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

10.  Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element.

Authors:  P E Kroeger; K D Sarge; R I Morimoto
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272
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