Literature DB >> 9797244

In vitro activity of a new polyene, SPA-S-843, against yeasts.

C Rimaroli1, T Bruzzese.   

Abstract

The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.

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Year:  1998        PMID： 9797244      PMCID： PMC105984     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Candida species: emerging hospital bloodstream pathogens.

Authors:  R P Wenzel; M A Pfaller
Journal:  Infect Control Hosp Epidemiol       Date:  1991-09       Impact factor: 3.254

2.  Detection of amphotericin B-resistant Candida isolates in a broth-based system.

Authors:  J H Rex; C R Cooper; W G Merz; J N Galgiani; E J Anaissie
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191

Review 3.  Mycoses caused by Candida lusitaniae.

Authors:  T L Hadfield; M B Smith; R E Winn; M G Rinaldi; C Guerra
Journal:  Rev Infect Dis       Date:  1987 Sep-Oct

4.  In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts.

Authors:  J N Galgiani; M L Lewis
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

Review 5.  Amphotericin B nephrotoxicity.

Authors:  R Sabra; R A Branch
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

6.  Quality control guidelines for National Committee for Clinical Laboratory Standards recommended broth macrodilution testing of amphotericin B, fluconazole, and flucytosine.

Authors:  M A Pfaller; M Bale; B Buschelman; M Lancaster; A Espinel-Ingroff; J H Rex; M G Rinaldi; C R Cooper; M R McGinnis
Journal:  J Clin Microbiol       Date:  1995-05       Impact factor: 5.948

7.  Infection control: opportunistic fungal infections--the increasing importance of Candida species.

Authors:  M A Pfaller
Journal:  Infect Control Hosp Epidemiol       Date:  1989-06       Impact factor: 3.254

8.  Fluconazole resistance in Candida glabrata.

Authors:  C A Hitchcock; G W Pye; P F Troke; E M Johnson; D W Warnock
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

9.  Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolates.

Authors:  A Wanger; K Mills; P W Nelson; J H Rex
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

Review 10.  Impact of the changing epidemiology of fungal infections in the 1990s.

Authors:  M Pfaller; R Wenzel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-04       Impact factor: 3.267
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  2 in total

Review 1.  SPK-843 (Aparts/Kaken).

Authors:  Noer Kasanah; Mark T Hamann
Journal:  Curr Opin Investig Drugs       Date:  2005-08

2.  Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.

Authors:  Hiroshi Kakeya; Yoshitsugu Miyazaki; Hisato Senda; Tsutomu Kobayashi; Masafumi Seki; Koichi Izumikawa; Yoshihiro Yamamoto; Kazunori Yanagihara; Takayoshi Tashiro; Shigeru Kohno
Journal:  Antimicrob Agents Chemother       Date:  2008-02-25       Impact factor: 5.191
  2 in total

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