Literature DB >> 18299408

Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.

Hiroshi Kakeya1, Yoshitsugu Miyazaki, Hisato Senda, Tsutomu Kobayashi, Masafumi Seki, Koichi Izumikawa, Yoshihiro Yamamoto, Kazunori Yanagihara, Takayoshi Tashiro, Shigeru Kohno.   

Abstract

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

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Year:  2008        PMID： 18299408      PMCID： PMC2346668          DOI： 10.1128/AAC.01370-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Preliminary study on in vitro activity and cytotoxicity on cell cultures of a new polyene antifungal molecule (SPA-S-843).

Authors:  A Pessina; L Rossoni; M Piccirillo; G Sala; M G Neri
Journal:  Eur J Pharm Biopharm       Date:  1999-03       Impact factor: 5.571

2.  In vitro activity of a new polyene SPK-843 against Candida spp, Cryptococcus neoformans and Aspergillus spp clinical isolates.

Authors:  A S Kantarcioglu; A Yucel; V Vidotto
Journal:  J Chemother       Date:  2003-06       Impact factor: 1.714

3.  Comparative pharmacokinetics of three preparations of the new antifungal SPK-843.

Authors:  T Bruzzese; M R Galmozzi; V M Ferrari; P Sala; A Bonabello
Journal:  Chemotherapy       Date:  2001-12       Impact factor: 2.544

4.  A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary cryptococcosis.

Authors:  H Kakeya; H Udono; N Ikuno; Y Yamamoto; K Mitsutake; T Miyazaki; K Tomono; H Koga; T Tashiro; E Nakayama; S Kohno
Journal:  Infect Immun       Date:  1997-05       Impact factor: 3.441

5.  Pharmacokinetics in rats of n-dimethylaminoacetyl-partricin a 2-dimethylaminoethylamide diascorbate (spk-843).

Authors:  T Bruzzese; M R Galmozzi; G Buffa; P Sala; A Bonabello
Journal:  Chemotherapy       Date:  2001 Mar-Apr       Impact factor: 2.544

6.  In vitro activity of a new polyene, SPA-S-843, against yeasts.

Authors:  C Rimaroli; T Bruzzese
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

7.  Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis.

Authors:  Robert A Larsen; Madeline Bauer; Ann M Thomas; J Richard Graybill
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
  7 in total
  3 in total

1.  Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.

Authors:  Ruth A Bryan; Zewei Jiang; Robertha C Howell; Alfred Morgenstern; Frank Bruchertseifer; Arturo Casadevall; Ekaterina Dadachova
Journal:  J Infect Dis       Date:  2010-08-15       Impact factor: 5.226

2.  Radiolabeled antibodies for therapy of infectious diseases.

Authors:  Ekaterina Dadachova; Arturo Casadevall
Journal:  Microbiol Spectr       Date:  2014-11

3.  Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections.

Authors:  Ekaterina Dadachova; Arturo Casadevall
Journal:  Interdiscip Perspect Infect Dis       Date:  2011-05-24
  3 in total

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