| Literature DB >> 9796444 |
J Park1, D S English, Y Wannemuehler, S Carpenter, J W Petrich.
Abstract
The light-induced antiviral activity of hypericin and hypocrellin in the presence and absence of oxygen was examined under experimental conditions where the effect of oxygen depletion could be quantified. There was a significant reduction of light-induced antiviral activity of hypericin and hypocrellin under hypoxic conditions. Interestingly, antiviral activity of hypocrellin was not observed at low oxygen levels at which hypericin retained measurable virucidal activity. This suggests that additional pathways, such as the generation of protons from excited states of hypericin, may enhance the biological activity of activated oxygen species.Entities:
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Year: 1998 PMID： 9796444
Source DB: PubMed Journal: Photochem Photobiol ISSN： 0031-8655 Impact factor: 3.421