Literature DB >> 15504880

Antimicrobial and antileishmanial activities of hypocrellins A and B.

Guoyi Ma1, Shabana I Khan, Melissa R Jacob, Babu L Tekwani, Zuqiang Li, David S Pasco, Larry A Walker, Ikhlas A Khan.   

Abstract

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15504880      PMCID： PMC525422          DOI： 10.1128/AAC.48.11.4450-4452.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs.

Authors:  Simon L Croft; Graham H Coombs
Journal:  Trends Parasitol       Date:  2003-11

Review 2.  Antifungal agents: in vitro susceptibility testing, pharmacodynamics, and prospects for combination therapy.

Authors:  A H Groll; H Kolve
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-03-11       Impact factor: 3.267

3.  [Clinical analysis and observation of hypocrellin photochemotherapy in the treatment of lichen amyloidosis: report of 37 cases].

Authors:  J B Wang; J N Bao
Journal:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao       Date:  1985-10

4.  [DNA single-strand breakage and its rejoining in HeLa cells caused by hypocrellin A photosensitization].

Authors:  E H Cao; L S Cheng
Journal:  Shi Yan Sheng Wu Xue Bao       Date:  1988-03

5.  A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

Authors:  J Mikus; D Steverding
Journal:  Parasitol Int       Date:  2000-01       Impact factor: 2.230

6.  Photoinactivation of virus infectivity by hypocrellin A.

Authors:  J Hirayama; K Ikebuchi; H Abe; K W Kwon; Y Ohnishi; M Horiuchi; M Shinagawa; K Ikuta; N Kamo; S Sekiguchi
Journal:  Photochem Photobiol       Date:  1997-11       Impact factor: 3.421

7.  Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide.

Authors:  Seyed Mohamed Ali; Soo Khee Chee; Gan Yik Yuen; Malini Olivo
Journal:  Int J Mol Med       Date:  2002-05       Impact factor: 4.101

8.  Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update.

Authors:  G G Miller; K Brown; A M Ballangrud; O Barajas; Z Xiao; J Tulip; J W Lown; J M Leithoff; M J Allalunis-Turner; R D Mehta; R B Moore
Journal:  Photochem Photobiol       Date:  1997-04       Impact factor: 3.421

9.  Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments.

Authors:  Z Diwu; J Zimmermann; T Meyer; J W Lown
Journal:  Biochem Pharmacol       Date:  1994-01-20       Impact factor: 5.858

Review 10.  Novel therapeutic and diagnostic applications of hypocrellins and hypericins.

Authors:  Z Diwu
Journal:  Photochem Photobiol       Date:  1995-06       Impact factor: 3.421
View more
  38 in total

1.  Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).

Authors:  Kirandeep Kaur; Meenakshi Jain; Shabana I Khan; Melissa R Jacob; Babu L Tekwani; Savita Singh; Prati Pal Singh; Rahul Jain
Journal:  Bioorg Med Chem       Date:  2010-11-25       Impact factor: 3.641

2.  Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

Authors:  Minkyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Raymond F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

3.  Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.

Authors:  Karumanchi V Rao; Marwa S Donia; Jiangnan Peng; Esther Garcia-Palomero; Diana Alonso; Ana Martinez; Miguel Medina; Scott G Franzblau; Babu L Tekwani; Shabana I Khan; Subagus Wahyuono; Kristine L Willett; Mark T Hamann
Journal:  J Nat Prod       Date:  2006-07       Impact factor: 4.050

4.  Antimicrobial, antimalarial, and antileishmanial activities of mono- and bis-quaternary pyridinium compounds.

Authors:  Sandip B Bharate; Charles M Thompson
Journal:  Chem Biol Drug Des       Date:  2010-10-11       Impact factor: 2.817

Review 5.  Anti-leishmanial and anti-trypanosomal natural products from endophytes.

Authors:  Jean Baptiste Hzounda Fokou; Darline Dize; Gisele Marguerite Etame Loe; Moise Henri Julien Nko'o; Jean Pierre Ngene; Charles Christian Ngoule; Fabrice Fekam Boyom
Journal:  Parasitol Res       Date:  2021-01-06       Impact factor: 2.289

6.  Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens.

Authors:  Jiangtao Gao; Mohamed M Radwan; Francisco León; Xiaoning Wang; Melissa R Jacob; Babu L Tekwani; Shabana I Khan; Shari Lupien; Robert A Hill; Frank M Dugan; Horace G Cutler; Stephen J Cutler
Journal:  Med Chem Res       Date:  2011-11-11       Impact factor: 1.965

7.  δ-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens.

Authors:  Tryphon K Mazu; Jagan R Etukala; Melissa R Jacob; Shabana I Khan; Larry A Walker; Seth Y Ablordeppey
Journal:  Eur J Med Chem       Date:  2011-03-17       Impact factor: 6.514

Review 8.  Leishmaniasis treatment--a challenge that remains: a review.

Authors:  Dilvani O Santos; Carlos E R Coutinho; Maria F Madeira; Carolina G Bottino; Rodrigo T Vieira; Samara B Nascimento; Alice Bernardino; Saulo C Bourguignon; Suzana Corte-Real; Rosa T Pinho; Carlos Rangel Rodrigues; Helena C Castro
Journal:  Parasitol Res       Date:  2008-06       Impact factor: 2.289

9.  Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal, and anti-HIV activities.

Authors:  Nafees Ahmed; Keyur G Brahmbhatt; Shabana I Khan; Melissa Jacob; Babu L Tekwani; Sudeep Sabde; Debashis Mitra; Inder P Singh; Ikhlas A Khan; Kamlesh K Bhutani
Journal:  Chem Biol Drug Des       Date:  2013-04       Impact factor: 2.817

10.  Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.

Authors:  Desmond Slade; Ahmed M Galal; Waseem Gul; Mohamed M Radwan; Safwat A Ahmed; Shabana I Khan; Babu L Tekwani; Melissa R Jacob; Samir A Ross; Mahmoud A Elsohly
Journal:  Bioorg Med Chem       Date:  2009-10-30       Impact factor: 3.641
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.