AIM: After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions. METHODS AND RESULTS: Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin-negative. The cases of DIP were CD68 positive but cytokeratin-negative. The adenocarcinoma was cytokeratin-positive (AE1/3 and CAM5.2), as well as showing some CD68-positive cells. Markers for carcinoma (CEA, Ber-EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes. CONCLUSION: Before a diagnosis of DIP is made, cytokeratin markers should be used.
AIM: After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions. METHODS AND RESULTS: Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin-negative. The cases of DIP were CD68 positive but cytokeratin-negative. The adenocarcinoma was cytokeratin-positive (AE1/3 and CAM5.2), as well as showing some CD68-positive cells. Markers for carcinoma (CEA, Ber-EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes. CONCLUSION: Before a diagnosis of DIP is made, cytokeratin markers should be used.
Authors: Kyuichi Kadota; Jun-Ichi Nitadori; Camelia S Sima; Hideki Ujiie; Nabil P Rizk; David R Jones; Prasad S Adusumilli; William D Travis Journal: J Thorac Oncol Date: 2015-05 Impact factor: 15.609
Authors: Arnaud Besson; Harry C Hwang; Samantha Cicero; Stacy L Donovan; Mark Gurian-West; Dianna Johnson; Bruce E Clurman; Michael A Dyer; James M Roberts Journal: Genes Dev Date: 2007-07-12 Impact factor: 11.361
Authors: Katsura Emoto; Takashi Eguchi; Kay See Tan; Yusuke Takahashi; Rania G Aly; Natasha Rekhtman; William D Travis; Prasad S Adusumilli Journal: J Thorac Oncol Date: 2019-07-25 Impact factor: 15.609