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Literature DB >> 9755135

Update on national toxicology program (NTP) assays with genetically altered or "transgenic" mice.

Abstract

The NTP is evaluating several lines of genetically altered mice for possible use in identifying and assessing carcinogens. The NIEHS/NTP programs and progress in this area were recently reviewed by the NTP Board of Scientific Counselors (BSC). A number of comments and concerns were raised. This commentary summarizes and responds to the BSC review and offers some thoughts on future directions for this line of research as well as possible ways genetically altered mice might be integrated into a comprehensive testing strategy.

Entities: Species

Mesh：

Year: 1998 PMID： 9755135 PMCID： PMC1533198 DOI： 10.1289/ehp.98106619

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

3 in total

1. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene.

Authors: S Yamamoto; Y Hayashi; K Mitsumori; T Nomura
Journal: Lab Anim Sci Date: 1997-04

2. Genetic background alters the spectrum of tumors that develop in p53-deficient mice.

Authors: M Harvey; M J McArthur; C A Montgomery; A Bradley; L A Donehower
Journal: FASEB J Date: 1993-07 Impact factor: 5.191

3. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.

Authors: R W Tennant; J E French; J W Spalding
Journal: Environ Health Perspect Date: 1995-10 Impact factor: 9.031

3 in total

8 in total

1. The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Authors: Takeki Uehara; Igor P Pogribny; Ivan Rusyn
Journal: Curr Protoc Pharmacol Date: 2014-09-02

2. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

Authors: Takeki Uehara; Garrett R Ainslie; Kristi Kutanzi; Igor P Pogribny; Levan Muskhelishvili; Takeshi Izawa; Jyoji Yamate; Oksana Kosyk; Svitlana Shymonyak; Blair U Bradford; Gary A Boorman; Ramon Bataller; Ivan Rusyn
Journal: Toxicol Sci Date: 2013-01-03 Impact factor: 4.849

Update on national toxicology program (NTP) assays with genetically altered or "transgenic" mice.

1. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene.

2. Genetic background alters the spectrum of tumors that develop in p53-deficient mice.

3. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.

1. The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

2. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

Review 3. The use of genetically modified mice in cancer risk assessment: challenges and limitations.

Review 4. The role of transgenic mouse models in carcinogen identification.

5. The "new" genetics and mammalian cloning in environmental health research.

6. Public health policy and the National Toxicology Program.

7. The DEN and CCl₄ -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

8. Human exposure assessment and the National Toxicology Program.