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Literature DB >> 9736730

Genetic code origins: tRNAs older than their synthetases?

L Ribas de Pouplana¹, R J Turner, B A Steer, P Schimmel.

Abstract

We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase. The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences previously had not allowed a formal comparison of their relative time of appearance. Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1998 PMID： 9736730 PMCID： PMC21636 DOI： 10.1073/pnas.95.19.11295

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

Review 1. Structural and functional relationships between aminoacyl-tRNA synthetases.

Authors: D Moras
Journal: Trends Biochem Sci Date: 1992-04 Impact factor: 13.807

2. Unusual resistance of peptidyl transferase to protein extraction procedures.

Authors: H F Noller; V Hoffarth; L Zimniak
Journal: Science Date: 1992-06-05 Impact factor: 47.728

Review 3. Biological catalysis by RNA.

Authors: T R Cech; B L Bass
Journal: Annu Rev Biochem Date: 1986 Impact factor: 23.643

Review 4. Catalysis by the RNA subunit of RNase P--a minireview.

Authors: S Altman; M F Baer; M Bartkiewicz; H Gold; C Guerrier-Takada; L A Kirsebom; N Lumelsky; K Peck
Journal: Gene Date: 1989-10-15 Impact factor: 3.688

5. tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis.

Authors: A M Weiner; N Maizels
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

6. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.

Authors: G Eriani; M Delarue; O Poch; J Gangloff; D Moras
Journal: Nature Date: 1990-09-13 Impact factor: 49.962

7. Aminoacyl esterase activity of the Tetrahymena ribozyme.

Authors: J A Piccirilli; T S McConnell; A J Zaug; H F Noller; T R Cech
Journal: Science Date: 1992-06-05 Impact factor: 47.728

8. Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae.

Authors: S W Ludmerer; P Schimmel
Journal: J Biol Chem Date: 1987-08-05 Impact factor: 5.157

Genetic code origins: tRNAs older than their synthetases?

Review 1. Structural and functional relationships between aminoacyl-tRNA synthetases.

2. Unusual resistance of peptidyl transferase to protein extraction procedures.

Review 3. Biological catalysis by RNA.

Review 4. Catalysis by the RNA subunit of RNase P--a minireview.

5. tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis.

6. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.

7. Aminoacyl esterase activity of the Tetrahymena ribozyme.

8. Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae.

9. Phylogenetic analysis of the spirochetes.

10. Specific sequence homology and three-dimensional structure of an aminoacyl transfer RNA synthetase.

1. An in vitro evolved precursor tRNA with aminoacylation activity.

2. Testing ancient RNA-protein interactions.

3. A minihelix-loop RNA acts as a trans-aminoacylation catalyst.

4. Minihelix-loop RNAs: minimal structures for aminoacylation catalysts.

5. On the evolution of primitive genetic codes.

6. Functional annotation of class I lysyl-tRNA synthetase phylogeny indicates a limited role for gene transfer.

7. The RNA origin of transfer RNA aminoacylation and beyond.

8. Emergence of the universal genetic code imprinted in an RNA record.

9. Genetic code origins: experiments confirm phylogenetic predictions and may explain a puzzle.

10. Substrate recognition by class I lysyl-tRNA synthetases: a molecular basis for gene displacement.