Literature DB >> 9733877

Establishment and characterization of a human Epstein-Barr virus-associated gastric carcinoma in SCID mice.

Y Iwasaki1, J M Chong, Y Hayashi, R Ikeno, K Arai, M Kitamura, M Koike, K Hirai, M Fukayama.   

Abstract

A transplantable human Epstein-Barr virus-associated gastric carcinoma (EBVaGC), designated KT, was propagated in severe combined immunodeficiency (SCID) mice for 12 passages. Mucin and cytokeratin expression and the Alu sequence in tumor DNA confirmed that the KT tumor was derived from human epithelial tissue. The identity of clonal EBV in the original and KT tumors was demonstrated by terminal repeat analysis of EBV DNA. The pattern of latency gene expression of EBV was the same in both tumors. EBER1 was presented similarly in tumor cell nuclei by in situ hybridization. Reverse transcription-PCR analysis also demonstrated Q-promoter-driven EBNA1 expression but not BZLF1, EBNA2, or LMP1 expression. Thus, the transplantable human EBVaGC KT retains the original EBV with the same latency gene expression and can serve as a model for this unique type of gastric carcinoma.

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Year:  1998        PMID： 9733877      PMCID： PMC110200     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

1.  Epstein-Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21.

Authors:  H Yoshiyama; S Imai; N Shimizu; K Takada
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

2.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

3.  Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus.

Authors:  J M Chong; M Fukayama; Y Hayashi; N Funata; T Takizawa; M Koike; M Muraoka; R Kikuchi-Yanoshita; M Miyaki; S Mizuno
Journal:  Int J Cancer       Date:  1997-08-22       Impact factor: 7.396

4.  EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx.

Authors:  H zur Hausen; H Schulte-Holthausen; G Klein; W Henle; G Henle; P Clifford; L Santesson
Journal:  Nature       Date:  1970-12-12       Impact factor: 49.962

5.  The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA.

Authors:  N Raab-Traub; K Flynn; G Pearson; A Huang; P Levine; A Lanier; J Pagano
Journal:  Int J Cancer       Date:  1987-01-15       Impact factor: 7.396

6.  Molecular cloning of an oncogene from a human hepatocellular carcinoma.

Authors:  T Ochiya; A Fujiyama; S Fukushige; I Hatada; K Matsubara
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

7.  Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells.

Authors:  M Sugiura; S Imai; M Tokunaga; S Koizumi; M Uchizawa; K Okamoto; T Osato
Journal:  Br J Cancer       Date:  1996-08       Impact factor: 7.640

8.  The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma.

Authors:  J Battey; C Moulding; R Taub; W Murphy; T Stewart; H Potter; G Lenoir; P Leder
Journal:  Cell       Date:  1983-10       Impact factor: 41.582

9.  Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

Authors:  A Neri; F Barriga; D M Knowles; I T Magrath; R Dalla-Favera
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

10.  Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma.

Authors:  P G Pelicci; D M Knowles; I Magrath; R Dalla-Favera
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205
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  16 in total

1.  Sequence variations of Epstein-Barr virus LMP2A gene in gastric carcinoma in Japan.

Authors:  M Tanaka; Y Kawaguchi; J Yokofujita; M Takagi; Y Eishi; K Hirai
Journal:  Virus Genes       Date:  1999       Impact factor: 2.332

Review 2.  Epstein-Barr virus and gastric carcinoma.

Authors:  K Takada
Journal:  Mol Pathol       Date:  2000-10

3.  In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.

Authors:  Hiroyuki Abe; Teppei Morikawa; Ruri Saito; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
Journal:  Virchows Arch       Date:  2016-02-25       Impact factor: 4.064

4.  Establishment and characterization of six human gastric carcinoma cell lines, including one naturally infected with Epstein-Barr virus.

Authors:  Ja-Lok Ku; Kyung-Hee Kim; Jin-Sung Choi; Sung-Hee Kim; Young-Kyoung Shin; Hee Jin Chang; Jae-Moon Bae; Young-Woo Kim; Jun Ho Lee; Han-Kwang Yang; Woo-Ho Kim; Seung-Yong Jeong; Jae-Gahb Park
Journal:  Cell Oncol (Dordr)       Date:  2012-02-24       Impact factor: 6.730

5.  Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis.

Authors:  Aya Shinozaki-Ushiku; Akiko Kunita; Maya Isogai; Takashi Hibiya; Tetsuo Ushiku; Kenzo Takada; Masashi Fukayama
Journal:  J Virol       Date:  2015-03-04       Impact factor: 5.103

6.  SOX9 expression and its methylation status in gastric cancer.

Authors:  Minhua Sun; Hiroshi Uozaki; Rumi Hino; Akiko Kunita; Aya Shinozaki; Tetsuo Ushiku; Takashi Hibiya; Kimiko Takeshita; Maya Isogai; Kenzo Takada; Masashi Fukayama
Journal:  Virchows Arch       Date:  2012-02-14       Impact factor: 4.064

7.  Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms.

Authors:  Hiroshi Uozaki; Masashi Fukayama
Journal:  Int J Clin Exp Pathol       Date:  2008-01-01

8.  ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability.

Authors:  Hiroyuki Abe; Daichi Maeda; Rumi Hino; Yuya Otake; Maya Isogai; Aya Shinozaki Ushiku; Keisuke Matsusaka; Akiko Kunita; Tetsuo Ushiku; Hiroshi Uozaki; Yoko Tateishi; Tsunekazu Hishima; Yoshiaki Iwasaki; Shumpei Ishikawa; Masashi Fukayama
Journal:  Virchows Arch       Date:  2012-08-23       Impact factor: 4.064

9.  Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection.

Authors:  Ja-Mun Chong; Kazuya Sakuma; Makoto Sudo; Toshio Osawa; Etsuko Ohara; Hiroshi Uozaki; Junji Shibahara; Kenji Kuroiwa; Shin-Ichi Tominaga; Yoshitaka Hippo; Hiroyuki Aburatani; Nobuaki Funata; Masashi Fukayama
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

Review 10.  Epstein-Barr Virus (EBV)-associated gastric carcinoma.

Authors:  Hisashi Iizasa; Asuka Nanbo; Jun Nishikawa; Masahisa Jinushi; Hironori Yoshiyama
Journal:  Viruses       Date:  2012-12       Impact factor: 5.048
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