Literature DB >> 9729546

Neutrophil chemiluminescence during phagocytosis is inhibited by abnormally elevated levels of acetoacetate: implications for diabetic susceptibility to infections.

F A Saeed1, G E Castle.   

Abstract

Human neutrophils by a chemiluminescence assay exhibit diminished phagocytic activity in the presence of abnormally high levels of the serum metabolite acetoacetate. These findings, along with our previous evidence demonstrating myeloperoxidase inhibition by acetoacetate, implicate metabolic ketosis in the inhibition of neutrophil microbicidal activity and thus in increased susceptibility to infections.

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Year:  1998        PMID： 9729546      PMCID： PMC95650          DOI： 10.1128/CDLI.5.5.740-743.1998

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  9 in total

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Authors:  J E Harrison; F A Saeed
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