Literature DB >> 15148570

Hyperglycaemia and mortality in critically ill patients. A prospective study.

Christian Christiansen1, Palle Toft, Hans Skriver Jørgensen, Søren Kaeseler Andersen, Else Tønnesen.   

Abstract

OBJECTIVE: To describe hyperglycaemia as a possible marker of morbidity and mortality in critically ill medical and surgical patients admitted to a multidisciplinary ICU.
DESIGN: Prospective cohort study.
SETTING: A 13-bed non-cardiac multidisciplinary ICU in a university hospital. PATIENTS AND PARTICIPANTS: Adult patients consecutively admitted to the ICU in a 6-month period. Patients with fewer than 2 days' stay in the ICU and patients with known diabetes were excluded. MEASUREMENTS AND
RESULTS: At admission a registration form was filled in including demographic data, first and second day APACHE II scores, infections and daily maximum blood glucose level. In surgical patients, high maximum blood glucose level during the stay in ICU was correlated with increased mortality, morbidity and frequency of infection. In medical patients, we found a non-significant trend towards a correlation between hyperglycaemia and morbidity and mortality, respectively.
CONCLUSIONS: High blood glucose level during the stay in ICU was a marker of increased morbidity and mortality in critically ill surgical patients. In medical patients the same trend was found, but non-significant. The population of patients in the present study are heterogeneous and the results from surgical critically ill patients should not be generalised to medical patients.

Entities:  

Mesh:

Year:  2004        PMID: 15148570     DOI: 10.1007/s00134-004-2325-2

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN: 0342-4642            Impact factor:   17.440


  14 in total

1.  Intensive insulin therapy in critically ill patients.

Authors:  G van den Berghe; P Wouters; F Weekers; C Verwaest; F Bruyninckx; M Schetz; D Vlasselaers; P Ferdinande; P Lauwers; R Bouillon
Journal:  N Engl J Med       Date:  2001-11-08       Impact factor: 91.245

Review 2.  Alterations in fuel metabolism in critical illness: hyperglycaemia.

Authors:  B A Mizock
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2001-12       Impact factor: 4.690

3.  Neutrophil chemiluminescence during phagocytosis is inhibited by abnormally elevated levels of acetoacetate: implications for diabetic susceptibility to infections.

Authors:  F A Saeed; G E Castle
Journal:  Clin Diagn Lab Immunol       Date:  1998-09

Review 4.  Alterations in carbohydrate metabolism during stress: a review of the literature.

Authors:  B A Mizock
Journal:  Am J Med       Date:  1995-01       Impact factor: 4.965

5.  The influence of hyperglycemia and diabetes mellitus on immediate and 3-month morbidity and mortality after acute stroke.

Authors:  J Woo; C W Lam; R Kay; A H Wong; R Teoh; M G Nicholls
Journal:  Arch Neurol       Date:  1990-11

6.  Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures.

Authors:  A P Furnary; K J Zerr; G L Grunkemeier; A Starr
Journal:  Ann Thorac Surg       Date:  1999-02       Impact factor: 4.330

Review 7.  Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview.

Authors:  S E Capes; D Hunt; K Malmberg; H C Gerstein
Journal:  Lancet       Date:  2000-03-04       Impact factor: 79.321

8.  The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM.

Authors:  R Moreno; J L Vincent; R Matos; A Mendonça; F Cantraine; L Thijs; J Takala; C Sprung; M Antonelli; H Bruining; S Willatts
Journal:  Intensive Care Med       Date:  1999-07       Impact factor: 17.440

9.  Association of hyperglycemia with increased mortality after severe burn injury.

Authors:  D C Gore; D Chinkes; J Heggers; D N Herndon; S E Wolf; M Desai
Journal:  J Trauma       Date:  2001-09

10.  Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year.

Authors:  K Malmberg; L Rydén; S Efendic; J Herlitz; P Nicol; A Waldenström; H Wedel; L Welin
Journal:  J Am Coll Cardiol       Date:  1995-07       Impact factor: 24.094

View more
  32 in total

1.  The metrics of glycaemic control in critical care.

Authors:  Iain M J Mackenzie; Tony Whitehouse; Peter G Nightingale
Journal:  Intensive Care Med       Date:  2011-01-06       Impact factor: 17.440

2.  Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS.

Authors:  Chau-Chyun Sheu; Michelle N Gong; Rihong Zhai; Feng Chen; Ednan K Bajwa; Peter F Clardy; Diana C Gallagher; B Taylor Thompson; David C Christiani
Journal:  Chest       Date:  2010-05-27       Impact factor: 9.410

3.  Risk of type 2 diabetes mellitus in patients with acute critical illness: a population-based cohort study.

Authors:  Chin-Wang Hsu; Chin-Sheng Lin; Sy-Jou Chen; Shih-Hua Lin; Cheng-Li Lin; Chia-Hung Kao
Journal:  Intensive Care Med       Date:  2015-09-14       Impact factor: 17.440

4.  Mean glucose level is not an independent risk factor for mortality in mixed ICU patients.

Authors:  Jack J M Ligtenberg; Sofie Meijering; Ymkje Stienstra; Iwan C C van der Horst; Mathijs Vogelzang; Maarten W N Nijsten; Jaap E Tulleken; Jan G Zijlstra
Journal:  Intensive Care Med       Date:  2006-02-14       Impact factor: 17.440

5.  Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress.

Authors:  Gerd G Gauglitz; Stefanie Halder; Darren F Boehning; Gabriela A Kulp; David N Herndon; José M Barral; Marc G Jeschke
Journal:  Shock       Date:  2010-03       Impact factor: 3.454

6.  Parenteral glucose and glucose control in the critically ill: a kinetic appraisal.

Authors:  Roman Hovorka; Jeremy Cordingley
Journal:  J Diabetes Sci Technol       Date:  2007-05

7.  Autoregressive Modeling of Drift and Random Error to Characterize a Continuous Intravascular Glucose Monitoring Sensor.

Authors:  Tony Zhou; Jennifer L Dickson; J Geoffrey Chase
Journal:  J Diabetes Sci Technol       Date:  2017-07-14

8.  Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients.

Authors:  Janett Kreutziger; Volker Wenzel; Andrea Kurz; Mihai Adrian Constantinescu
Journal:  Intensive Care Med       Date:  2009-02-24       Impact factor: 17.440

9.  A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes.

Authors:  Ivan Gornik; Ana Vujaklija-Brajkovic; Ivana Pavlic Renar; Vladimir Gasparovic
Journal:  Crit Care       Date:  2010-07-08       Impact factor: 9.097

10.  Overview of glycemic control in critical care: relating performance and clinical results.

Authors:  J Geoffrey Chase; Christopher E Hann; Geoffrey M Shaw; Jason Wong; Jessica Lin; Thomas Lotz; Aaron Lecompte; Timothy Lonergan
Journal:  J Diabetes Sci Technol       Date:  2007-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.