Literature DB >> 9729300

Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain.

R Bunzel1, I Blümcke, S Cichon, S Normann, J Schramm, P Propping, M M Nöthen.   

Abstract

We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9729300     DOI： 10.1016/s0169-328x(98)00146-6

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  34 in total

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