Literature DB >> 9729045

CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.

A Cerutti1, A Schaffer, S Shah, H Zan, H C Liou, R G Goodwin, P Casali.   

Abstract

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.

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Year:  1998        PMID： 9729045      PMCID： PMC4621001          DOI： 10.1016/s1074-7613(00)80607-x

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  44 in total

1.  A CD30 responsive element in the germline epsilon promoter that is distinct from and inhibitory to the CD40 response element.

Authors:  M D Jumper; K Fujita; P E Lipsky; K Meek
Journal:  Mol Immunol       Date:  1996-08       Impact factor: 4.407

2.  Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells.

Authors:  S H Hanissian; R S Geha
Journal:  Immunity       Date:  1997-04       Impact factor: 31.745

3.  Identification and characterization of an IkappaB kinase.

Authors:  C H Régnier; H Y Song; X Gao; D V Goeddel; Z Cao; M Rothe
Journal:  Cell       Date:  1997-07-25       Impact factor: 41.582

4.  CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.

Authors:  C S Duckett; C B Thompson
Journal:  Genes Dev       Date:  1997-11-01       Impact factor: 11.361

5.  B cell differentiation and isotype switching is related to division cycle number.

Authors:  P D Hodgkin; J H Lee; A B Lyons
Journal:  J Exp Med       Date:  1996-07-01       Impact factor: 14.307

6.  CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.

Authors:  C A Smith; H J Gruss; T Davis; D Anderson; T Farrah; E Baker; G R Sutherland; C I Brannan; N G Copeland; N A Jenkins
Journal:  Cell       Date:  1993-07-02       Impact factor: 41.582

7.  Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.

Authors:  T Takai; M Ono; M Hikida; H Ohmori; J V Ravetch
Journal:  Nature       Date:  1996-01-25       Impact factor: 49.962

8.  Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands.

Authors:  M D Jumper; Y Nishioka; L S Davis; P E Lipsky; K Meek
Journal:  J Immunol       Date:  1995-09-01       Impact factor: 5.422

9.  Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.

Authors:  E Stüber; M Neurath; D Calderhead; H P Fell; W Strober
Journal:  Immunity       Date:  1995-05       Impact factor: 31.745

10.  CTLA-4 ligation blocks CD28-dependent T cell activation.

Authors:  T L Walunas; C Y Bakker; J A Bluestone
Journal:  J Exp Med       Date:  1996-06-01       Impact factor: 14.307
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  23 in total

1.  The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.

Authors:  K M Izumi; E D Cahir McFarland; A T Ting; E A Riley; B Seed; E D Kieff
Journal:  Mol Cell Biol       Date:  1999-08       Impact factor: 4.272

2.  Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.

Authors:  H Zan; A Cerutti; P Dramitinos; A Schaffer; Z Li; P Casali
Journal:  J Immunol       Date:  1999-03-15       Impact factor: 5.422

Review 3.  Naive and memory B cells in T-cell-dependent and T-independent responses.

Authors:  R H Zubler
Journal:  Springer Semin Immunopathol       Date:  2001-12

4.  The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

Authors:  H Zan; A Komori; Z Li; A Cerutti; A Schaffer; M F Flajnik; M Diaz; P Casali
Journal:  Immunity       Date:  2001-05       Impact factor: 31.745

5.  DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.

Authors:  Mikhail B Litinskiy; Bernardetta Nardelli; David M Hilbert; Bing He; Andras Schaffer; Paolo Casali; Andrea Cerutti
Journal:  Nat Immunol       Date:  2002-08-05       Impact factor: 25.606

6.  Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.

Authors:  Montserrat Cols; Carolina M Barra; Bing He; Irene Puga; Weifeng Xu; April Chiu; Wayne Tam; Daniel M Knowles; Stacey R Dillon; John P Leonard; Richard R Furman; Kang Chen; Andrea Cerutti
Journal:  J Immunol       Date:  2012-05-16       Impact factor: 5.422

Review 7.  Roles of TRAF molecules in B lymphocyte function.

Authors:  Ping Xie; Zachary J Kraus; Laura L Stunz; Gail A Bishop
Journal:  Cytokine Growth Factor Rev       Date:  2008-05-21       Impact factor: 7.638

8.  CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.

Authors:  H Zan; A Cerutti; P Dramitinos; A Schaffer; P Casali
Journal:  J Immunol       Date:  1998-11-15       Impact factor: 5.422

9.  Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF.

Authors:  Weifeng Xu; Paul A Santini; Allysia J Matthews; April Chiu; Alessandro Plebani; Bing He; Kang Chen; Andrea Cerutti
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422

10.  BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

Authors:  Danielle T Avery; Susan L Kalled; Julia I Ellyard; Christine Ambrose; Sarah A Bixler; Marilyn Thien; Robert Brink; Fabienne Mackay; Philip D Hodgkin; Stuart G Tangye
Journal:  J Clin Invest       Date:  2003-07       Impact factor: 14.808
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