Literature DB >> 12154359

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.

Mikhail B Litinskiy1, Bernardetta Nardelli, David M Hilbert, Bing He, Andras Schaffer, Paolo Casali, Andrea Cerutti.   

Abstract

Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand. In the presence of interleukin 10 (IL-10) or transforming growth factor-beta, BLyS and APRIL induce CSR from C(mu) to C(gamma) and/or C(alpha) genes in B cells, whereas CSR to C(epsilon) requires IL-4. Secretion of class-switched antibodies requires additional stimulation by B cell antigen receptor engagement and IL-15. By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.

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Year:  2002        PMID： 12154359      PMCID： PMC4621779          DOI： 10.1038/ni829

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


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