Literature DB >> 6311204

The presence of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) in human platelets.

J Lüthje, A Ogilvie.   

Abstract

Diadenosine triphosphate (Ap3A) has been identified and quantified in human platelets using a coupled enzymatic assay specific for Ap3A, after fractionation of acidic extracts with high-performance liquid chromatography. Upon thrombin-induced aggregation, Ap3A is released together with the homologue diadenosine tetraphosphate (Ap4A). Extracts of human platelets do also contain enzymatic activities that degrade diadenosine tetraphosphate as well as diadenosine triphosphate. These enzymes, however, are not released during thrombin-induced aggregation of the platelets.

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Year:  1983        PMID： 6311204     DOI： 10.1016/0006-291x(83)90997-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  36 in total

1.  Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.

Authors:  E Castro; J Pintor; M T Miras-Portugal
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

2.  Antithrombotic effect of beta,beta'-monochloromethylene diadenosine 5',5"'-P1,P4-tetraphosphate.

Authors:  B K Kim; P Zamecnik; G Taylor; M J Guo; G M Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

Review 3.  Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.

Authors:  Vera Jankowski; Markus van der Giet; Harald Mischak; Michael Morgan; Walter Zidek; Joachim Jankowski
Journal:  Br J Pharmacol       Date:  2009-06-25       Impact factor: 8.739

4.  Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.

Authors:  G M Blackburn; X Liu; A Rösler; C Brenner
Journal:  Nucleosides Nucleotides       Date:  1998 Jan-Mar

5.  Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein.

Authors:  L Gasmi; A G McLennan; S W Edwards
Journal:  Immunology       Date:  1997-01       Impact factor: 7.397

6.  Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets.

Authors:  H Schlüter; I Grobeta; J Bachmann; R Kaufmann; M van der Giet; M Tepel; J R Nofer; G Assmann; M Karas; J Jankowski; W Zidek
Journal:  J Clin Invest       Date:  1998-02-01       Impact factor: 14.808

7.  Specific magnesium-dependent diadenosine 5',5'''-P1,P3-triphosphate pyrophosphohydrolase in Escherichia coli.

Authors:  C Hurtado; A Ruíz; A Sillero; M A Sillero
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

8.  Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.

Authors:  J Pintor; M A Díaz-Rey; M T Miras-Portugal
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

9.  The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates.

Authors:  C H Hoyle; A U Ziganshin; J Pintor; G Burnstock
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

10.  Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents.

Authors:  P C Zamecnik; B Kim; M J Gao; G Taylor; G M Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205
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