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Literature DB >> 720481

Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain.

A Algeri, A Consolazione, G Calderini, G Achilli, E P Canas, S Garattini.

Abstract

The effect of cerebroventricular injection of [D-Alanine] methionine-enkephalin (DALA), a synthetic analog of met-enkephalin, on the serotonergic system of rat brain has been studied. This opioid peptide caused an increase in 5HT turnover which was particularly evident in the limbic forebrain. This effect was completely antagonized by naloxone pretreatment.

Entities: Chemical Gene Species

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Year: 1978 PMID： 720481 DOI： 10.1007/bf01932370

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. Analgesia induced in vivo by central administration of enkephalin in rat.

Authors: J D Belluzzi; N Grant; V Garsky; D Sarantakis; C D Wise; L Stein
Journal: Nature Date: 1976-04-15 Impact factor: 49.962

2. The C-fragment of beta-lipotropin: an endogenous neuroleptic or antipsychotogen?

Authors: Y F Jacquet; N Marks
Journal: Science Date: 1976-11-05 Impact factor: 47.728

3. Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates.

Authors: J M Hambrook; B A Morgan; M J Rance; C F Smith
Journal: Nature Date: 1976-08-26 Impact factor: 49.962

4. Effect of acutely administered analgesic drugs on rat brain serotonin turnover.

Authors: I Goodlet; M F Sugrue
Journal: Eur J Pharmacol Date: 1974-12 Impact factor: 4.432

5. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain.

Authors: G Curzon; A R Green
Journal: Br J Pharmacol Date: 1970-07 Impact factor: 8.739

2. Similarities and differences between D-ALA2 MET5 enkephalin amide and morphine in the induction of tolerance to their effects on catalepsy and on dopamine metabolism in the rat brain.

Authors: M G De Simoni; V Guardabasso; K Misterek; S Algeri
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1982-11 Impact factor: 3.000

2 in total

Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain.

1. Analgesia induced in vivo by central administration of enkephalin in rat.

2. The C-fragment of beta-lipotropin: an endogenous neuroleptic or antipsychotogen?

3. Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates.

4. Effect of acutely administered analgesic drugs on rat brain serotonin turnover.

5. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain.

6. Enkephalin catabolism in vitro and in vivo.

7. Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.

8. The determination of tryptophan in plasma, liver, and urine.

9. Identification of two related pentapeptides from the brain with potent opiate agonist activity.

10. (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.

1. Mapping, in the rat central nervous system, of morphine-induced changes in turnover of 5-hydroxytryptamine.

2. Similarities and differences between D-ALA2 MET5 enkephalin amide and morphine in the induction of tolerance to their effects on catalepsy and on dopamine metabolism in the rat brain.