Literature DB >> 729748

Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration.

V Locatelli, D Cocchi, S Bajusz, S Spampinato, E E Müller.   

Abstract

The growth hormone (GH) and prolactin releasing (PRL) activity of [D-Met2, Pro5]-enkephalinamide (EKNH2). an opioid peptide analog with higher opiate agonist activity that morphine, was compared in the unanesthetized male rat to those of equimolar doses of morphine upon systemic injection. EKNH2 proved to be a higher PRL, but not GH, releaser than the opiate alkaloid.

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Year:  1978        PMID： 729748     DOI： 10.1007/bf02034731

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin.

Authors:  D H Coy; A J Kastin; A V Schally; O Morin; N G Caron; F Labrie; J M Walker; R Fertel; G G Berntson; C A Sandman
Journal:  Biochem Biophys Res Commun       Date:  1976-12-06       Impact factor: 3.575

2.  Analgesia induced in vivo by central administration of enkephalin in rat.

Authors:  J D Belluzzi; N Grant; V Garsky; D Sarantakis; C D Wise; L Stein
Journal:  Nature       Date:  1976-04-15       Impact factor: 49.962

3.  Enkephalin-stimulated prolactin release.

Authors:  E L Lien; R L Fenichel; V Garsky; D Sarantakis; N H Grant
Journal:  Life Sci       Date:  1976-09-15       Impact factor: 5.037

4.  (D-met2, pro5)-enkephalinamide: a potent morphine-like analgesic.

Authors:  J I Székely; A Z Rónai; Z Dunai-Kovács; E Miglécz; I Berzétri; S Bajusz; L Gráf
Journal:  Eur J Pharmacol       Date:  1977-06-01       Impact factor: 4.432

5.  Leu-enkephalin-stimulated growth hormone and prolactin release in the rat: comparison with the effect of morphine.

Authors:  D Cocchi; A Santagostino; I Gil-Ad; S Ferri; E E Müller
Journal:  Life Sci       Date:  1977-06-15       Impact factor: 5.037

6.  Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin--evidence for regulation by an endogenous opioid peptide in brain.

Authors:  C J Shaar; R C Frederickson; N B Dininger; L Jackson
Journal:  Life Sci       Date:  1977-09-15       Impact factor: 5.037

7.  Comparison of the analgesic properties of lipotropin C-fragment and stabilized enkephalins in the rat.

Authors:  A F Bradbury; D G Smyth; C R Snell; J F Deakin; S Wendlandt
Journal:  Biochem Biophys Res Commun       Date:  1977-01-24       Impact factor: 3.575

8.  Plasma growth hormone concentration in the rat determined by radioimmunoassay: influence of sex, pregnancy, lactation, anesthesia, hypophysectomy and extrasellar pituitary transplants.

Authors:  D S Schalch; S Reichlin
Journal:  Endocrinology       Date:  1966-08       Impact factor: 4.736

9.  (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.

Authors:  C B Pert; A Pert; J K Chang; B T Fong
Journal:  Science       Date:  1976-10-15       Impact factor: 47.728

10.  Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.

Authors:  C Rivier; W Vale; N Ling; M Brown; R Guillemin
Journal:  Endocrinology       Date:  1977-01       Impact factor: 4.736
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