Literature DB >> 9661005

Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.

A Haimeur1, M Ouellette.   

Abstract

Leishmania tarentolae promastigotes were selected step by step for resistance to sodium stibogluconate (Pentostam). Mutants resistant to antimony-containing drugs and cross-resistant to arsenite were therefore obtained. Amplification of one common locus was observed in several independent sodium stibogluconate-resistant mutants, and the locus amplified was novel. The copy number of the amplified locus was related to the level of resistance to pentavalent antimony. The gene responsible for antimony resistance was isolated by transfection and was shown to correspond to an open reading frame coding for 770 amino acids. The putative gene product did not exhibit significant homology with sequences present in data banks, and the putative role of this protein in antimony resistance is discussed.

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Year:  1998        PMID： 9661005      PMCID： PMC105667     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  38 in total

Review 1.  Gene amplification in Leishmania.

Authors:  S M Beverley
Journal:  Annu Rev Microbiol       Date:  1991       Impact factor: 15.500

2.  Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption.

Authors:  M Ouellette; A Haimeur; K Grondin; D Légaré; B Papadopoulou
Journal:  Methods Enzymol       Date:  1998       Impact factor: 1.600

3.  Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania.

Authors:  D Légaré; B Papadopoulou; G Roy; R Mukhopadhyay; A Haimeur; S Dey; K Grondin; C Brochu; B P Rosen; M Ouellette
Journal:  Exp Parasitol       Date:  1997-11       Impact factor: 2.011

4.  An axenic amastigote system for drug screening.

Authors:  H L Callahan; A C Portal; R Devereaux; M Grogl
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

5.  Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes.

Authors:  M Ephros; E Waldman; D Zilberstein
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

6.  ABC transporters in Leishmania and their role in drug resistance.

Authors:  M Ouellette; D Légaré; A Haimeur; K Grondin; G Roy; C Brochu; B Papadopoulou
Journal:  Drug Resist Updat       Date:  1998-03       Impact factor: 18.500

7.  Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Authors:  J A Coderre; S M Beverley; R T Schimke; D V Santi
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

Authors:  T C White; F Fase-Fowler; H van Luenen; J Calafat; P Borst
Journal:  J Biol Chem       Date:  1988-11-15       Impact factor: 5.157

9.  Autonomous replication of bacterial DNA plasmid oligomers in Leishmania.

Authors:  B Papadopoulou; G Roy; M Ouellette
Journal:  Mol Biochem Parasitol       Date:  1994-05       Impact factor: 1.759

10.  Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance.

Authors:  B Papadopoulou; G Roy; S Dey; B P Rosen; M Ouellette
Journal:  J Biol Chem       Date:  1994-04-22       Impact factor: 5.157
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  24 in total

1.  Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility.

Authors:  Maria Claudia Barrera; Laura Jimena Rojas; Austin Weiss; Olga Fernandez; Diane McMahon-Pratt; Nancy G Saravia; Maria Adelaida Gomez
Journal:  Acta Trop       Date:  2017-08-24       Impact factor: 3.112

2.  Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.

Authors:  Tim Downing; Hideo Imamura; Saskia Decuypere; Taane G Clark; Graham H Coombs; James A Cotton; James D Hilley; Simonne de Doncker; Ilse Maes; Jeremy C Mottram; Mike A Quail; Suman Rijal; Mandy Sanders; Gabriele Schönian; Olivia Stark; Shyam Sundar; Manu Vanaerschot; Christiane Hertz-Fowler; Jean-Claude Dujardin; Matthew Berriman
Journal:  Genome Res       Date:  2011-10-28       Impact factor: 9.043

3.  Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani.

Authors:  M Wiesgigl; J Clos
Journal:  Mol Biol Cell       Date:  2001-11       Impact factor: 4.138

4.  The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis.

Authors:  K C Carter; S Sundar; C Spickett; O C Pereira; A B Mullen
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

5.  Efficacies of vesicular and free sodium stibogluconate formulations against clinical isolates of Leishmania donovani.

Authors:  K C Carter; A B Mullen; S Sundar; R T Kenney
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

6.  Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites.

Authors:  Christian Brochu; Jingyu Wang; Gaétan Roy; Nadine Messier; Xiao-Yan Wang; Nancy G Saravia; Marc Ouellette
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

7.  Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance.

Authors:  Fabricio C Dias; Jeronimo C Ruiz; Wilton C Z Lopes; Fabio M Squina; Adriana Renzi; Angela K Cruz; Luiz R O Tosi
Journal:  Parasitol Res       Date:  2007-03-29       Impact factor: 2.289

8.  Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.

Authors:  M Ephros; A Bitnun; P Shaked; E Waldman; D Zilberstein
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

9.  Heterogeneity of molecular resistance patterns in antimony-resistant field isolates of Leishmania species from the western Mediterranean area.

Authors:  Fakhri Jeddi; Charles Mary; Karim Aoun; Zoubir Harrat; Aïda Bouratbine; Françoise Faraut; Rezika Benikhlef; Christelle Pomares; Francine Pratlong; Pierre Marty; Renaud Piarroux
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

10.  Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.

Authors:  Chantal Guimond; Nathalie Trudel; Christian Brochu; Nathalie Marquis; Amal El Fadili; Régis Peytavi; Guylaine Briand; Dave Richard; Nadine Messier; Barbara Papadopoulou; Jacques Corbeil; Michel G Bergeron; Danielle Légaré; Marc Ouellette
Journal:  Nucleic Acids Res       Date:  2003-10-15       Impact factor: 16.971
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