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Literature DB >> 17092795

ABC transporters in Leishmania and their role in drug resistance.

M Ouellette¹, D Légaré, A Haimeur, K Grondin, G Roy, C Brochu, B Papadopoulou.

Abstract

ABC transporters have been found in several parasitic protozoa including Leishmania. At least two Leishmania ABC transporters are involved in drug resistance. One is PgpA, which is involved in resistance to arsenic and antimony-containing compounds. Antimonials are the drug of choice against Leishmania infections. Transfection and biochemical studies suggest that PgpA recognizes metals conjugated to thiols. The second ABC transporter is closely related to mammalian P-glycoproteins and confers resistance to anticancer drugs by a mechanism that remains to be elucidated. Additional ABC transporters are likely to be present in Leishmania and these are discussed in relation to the phenomenon of antimony resistance.

Entities: Chemical Disease Gene Species

Year: 1998 PMID： 17092795 DOI： 10.1016/s1368-7646(98)80213-6

Source DB: PubMed Journal: Drug Resist Updat ISSN： 1368-7646 Impact factor: 18.500

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Cited

21 in total

1. Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.

Authors: Bidyut Purkait; Ashish Kumar; Nilay Nandi; Abul Hasan Sardar; Sushmita Das; Sudeep Kumar; Krishna Pandey; Vidyananda Ravidas; Manish Kumar; Tripti De; Dharmendra Singh; Pradeep Das
Journal: Antimicrob Agents Chemother Date: 2011-11-28 Impact factor: 5.191

Review 2. ABC proteins of Leishmania.

Authors: D Légaré; S Cayer; A K Singh; D Richard; B Papadopoulou; M Ouellette
Journal: J Bioenerg Biomembr Date: 2001-12 Impact factor: 2.945

3. High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

Authors: J M Pérez-Victoria; F J Pérez-Victoria; G Conseil; M Maitrejean; G Comte; D Barron; A Di Pietro; S Castanys; F Gamarro
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

4. DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening.

Authors: D Sereno; G Roy; J L Lemesre; B Papadopoulou; M Ouellette
Journal: Antimicrob Agents Chemother Date: 2001-04 Impact factor: 5.191

Review 5. Leishmania antimony resistance: what we know what we can learn from the field.

Authors: Khatima Aït-Oudhia; Elodie Gazanion; Baptiste Vergnes; Bruno Oury; Denis Sereno
Journal: Parasitol Res Date: 2011-07-29 Impact factor: 2.289

6. Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani.

Authors: Awanish Kumar; Brijesh Sisodia; Pragya Misra; Shyam Sundar; Ajit Kumar Shasany; Anuradha Dube
Journal: Br J Clin Pharmacol Date: 2010-10 Impact factor: 4.335

ABC transporters in Leishmania and their role in drug resistance.

1. Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.

Review 2. ABC proteins of Leishmania.

3. High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

4. DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening.

Review 5. Leishmania antimony resistance: what we know what we can learn from the field.

6. Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani.

7. Drug resistance in leishmaniasis.

Review 8. Transporters for drug delivery and as drug targets in parasitic protozoa.

9. Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.

10. Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.