Literature DB >> 9371094

Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania.

D Légaré1, B Papadopoulou, G Roy, R Mukhopadhyay, A Haimeur, S Dey, K Grondin, C Brochu, B P Rosen, M Ouellette.   

Abstract

The mechanism of resistance to the metal arsenite has been studied and compared in L. mexicana, L. tropica, and L. tarentolae selected in a step by step manner for arsenite resistance. Amplification of the ABC transporter gene pgpA was found to be a frequent resistance mechanism in all species. Transfection of pgpA genes into different species indicated that both the origin of the pgpA gene and the recipient strain into which the gene is transfected seem important for resistance. An increase in the levels of trypanothione was also correlated with metal resistance in different Leishmania species. The mechanism used to increase the levels of trypanothione seems to differ, however, between the different species. This study points to a key role of transporters and thiol levels in metal resistance in Leishmania.

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Year:  1997        PMID： 9371094     DOI： 10.1006/expr.1997.4222

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  25 in total

1.  Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line.

Authors:  Charles Anacleto; Maria C B Abdo; Adlane V B Ferreira; Silvane M F Murta; Alvaro J Romanha; Ana Paula Fernandes; Elizabeth S A Moreira
Journal:  Parasitol Res       Date:  2003-02-11       Impact factor: 2.289

Review 2.  ABC proteins of Leishmania.

Authors:  D Légaré; S Cayer; A K Singh; D Richard; B Papadopoulou; M Ouellette
Journal:  J Bioenerg Biomembr       Date:  2001-12       Impact factor: 2.945

3.  Drug target identification using a trypanosome overexpression library.

Authors:  Daniela Begolo; Esteban Erben; Christine Clayton
Journal:  Antimicrob Agents Chemother       Date:  2014-07-21       Impact factor: 5.191

4.  Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal.

Authors:  Saskia Decuypere; Suman Rijal; Vanessa Yardley; Simonne De Doncker; Thierry Laurent; Basudha Khanal; François Chappuis; Jean-Claude Dujardin
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

5.  A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum.

Authors:  Paloma Tejera Nevado; Eugenia Bifeld; Katharina Höhn; Joachim Clos
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

6.  The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis.

Authors:  K C Carter; S Sundar; C Spickett; O C Pereira; A B Mullen
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

7.  Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B.

Authors:  Tim J Vickers; Alan H Fairlamb
Journal:  J Biol Chem       Date:  2004-04-08       Impact factor: 5.157

8.  Frequency of drug resistance gene amplification in clinical leishmania strains.

Authors:  C Mary; F Faraut; M Deniau; J Dereure; K Aoun; S Ranque; R Piarroux
Journal:  Int J Microbiol       Date:  2010-07-12

9.  Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites.

Authors:  Christian Brochu; Jingyu Wang; Gaétan Roy; Nadine Messier; Xiao-Yan Wang; Nancy G Saravia; Marc Ouellette
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

10.  Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.

Authors:  M Ephros; A Bitnun; P Shaked; E Waldman; D Zilberstein
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191
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