Literature DB >> 9657851

A QTL with major effect on milk yield and composition maps to bovine chromosome 14.

W Coppieters1, J Riquet, J J Arranz, P Berzi, N Cambisano, B Grisart, L Karim, F Marcq, L Moreau, C Nezer, P Simon, P Vanmanshoven, D Wagenaar, M Georges.   

Abstract

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of a locus on the centromeric end of bovine Chromosome (Chr) 14, with major effect on fat and protein percentage as well as milk yield. The genuine nature of this QTL was verified using the grand2-daughter design, that is, by tracing the segregating QTL alleles from heterozygous grandsires to their maternal grandsons and confirming the predicted QTL allele substitution effect.

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Year:  1998        PMID： 9657851     DOI： 10.1007/s003359900815

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  20 in total

1.  Establishment of a high throughput EST sequencing system using poly(A) tail-removed cDNA libraries and determination of 36,000 bovine ESTs.

Authors:  A Takasuga; S Hirotsune; R Itoh; A Jitohzono; H Suzuki; H Aso; Y Sugimoto
Journal:  Nucleic Acids Res       Date:  2001-11-15       Impact factor: 16.971

2.  Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.

Authors:  Sarah Blott; Jong-Joo Kim; Sirja Moisio; Anne Schmidt-Küntzel; Anne Cornet; Paulette Berzi; Nadine Cambisano; Christine Ford; Bernard Grisart; Dave Johnson; Latifa Karim; Patricia Simon; Russell Snell; Richard Spelman; Jerry Wong; Johanna Vilkki; Michel Georges; Frédéric Farnir; Wouter Coppieters
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

3.  Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content.

Authors:  Andreas Winter; Wolfgang Krämer; Fabian A O Werner; Sonja Kollers; Srinivas Kata; Gregor Durstewitz; Johannes Buitkamp; James E Womack; Georg Thaller; Ruedi Fries
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-20       Impact factor: 11.205

4.  QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks.

Authors:  William S J Valdar; Jonathan Flint; Richard Mott
Journal:  Mamm Genome       Date:  2003-12       Impact factor: 2.957

5.  Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition.

Authors:  Bernard Grisart; Frédéric Farnir; Latifa Karim; Nadine Cambisano; Jong-Joo Kim; Alex Kvasz; Myriam Mni; Patricia Simon; Jean-Marie Frère; Wouter Coppieters; Michel Georges
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205

6.  Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.

Authors:  Latifa Karim; Haruko Takeda; Li Lin; Tom Druet; Juan A C Arias; Denis Baurain; Nadine Cambisano; Stephen R Davis; Frédéric Farnir; Bernard Grisart; Bevin L Harris; Mike D Keehan; Mathew D Littlejohn; Richard J Spelman; Michel Georges; Wouter Coppieters
Journal:  Nat Genet       Date:  2011-04-24       Impact factor: 38.330

7.  Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping.

Authors:  Cynthia Sandor; Frédéric Farnir; Sarah Hansoul; Wouter Coppieters; Théo Meuwissen; Michel Georges
Journal:  Genetics       Date:  2006-04-30       Impact factor: 4.562

8.  A whole genome scan for quantitative trait loci affecting milk protein percentage in Israeli-Holstein cattle, by means of selective milk DNA pooling in a daughter design, using an adjusted false discovery rate criterion.

Authors:  M O Mosig; E Lipkin; G Khutoreskaya; E Tchourzyna; M Soller; A Friedmann
Journal:  Genetics       Date:  2001-04       Impact factor: 4.562

9.  RNA interference-mediated knockdown of DGAT1 decreases triglyceride content of bovine mammary epithelial cell line.

Authors:  Chunyan Lu; Runjun Yang; Binglei Shen; Hassan Osman; Yonghong Zhang; Shouqing Yan; Liying Zhang; Zhihui Zhao
Journal:  Gene Expr       Date:  2012

10.  Genome wide association studies for milk production traits in Chinese Holstein population.

Authors:  Li Jiang; Jianfeng Liu; Dongxiao Sun; Peipei Ma; Xiangdong Ding; Ying Yu; Qin Zhang
Journal:  PLoS One       Date:  2010-10-27       Impact factor: 3.240
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