Cyclic AMP oscillations in Dictyostelium discoideum: models and observations.

Oscillations in intra- and extracellular cyclic AMP are believed to underlie aggregation and morphogenesis in Dictyostelium discoideum. Upon comparing mathematical models with observations we find that the models are, qualitatively speaking, quite successful. At the same time many features remain unexplained. A strong case can be made for cyclic AMP-independent oscillations whose basis remains to be explored.