| Literature DB >> 24255112 |
Abstract
The excitable cells of Dictyostelium discoideum show traveling waves of signaling and generate a variety of complex wave forms during their morphogenesis. Important among these wave forms is the 3D spiral or scroll wave, which has been proposed previously to have a twisted variant: the "turbine wave." Herein we argue that a D. discoideum scroll or concentric wave territory containing prespore and prestalk cell types can undergo "dislocation": a wave field that initially controls aggregation of a whole developing population of Dictyostelium cells splits into two. This process leads to discontinuity between two connected domains of wave propagation and to specific phenomena, including high-frequency concentric pacemaker activity by the slime mold's scroll-wave tip. The resulting morphogenetic events reveal a unique mechanism in morphogenesis.Entities:
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Year: 2013 PMID: 24255112 PMCID: PMC3856777 DOI: 10.1073/pnas.1300236110
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205