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Literature DB >> 965088

Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system.

M Imai, F C Tachibana, Y Moritsugu, Y Miyakawa, M Mayumi.

Abstract

Serum samples of 403 asymptomatic blood donors carrying hepatitis B surface antigen (HB5Ag) were concentrated threefold and tested for e antigen and antibody to e antigen (anti-e) by immunodiffusion. Hepatitis B antigen (HBAg)-associated deoxyribonucleic acid (DNA) polymerase activity was specifically determined by the difference in incorporation of [methyl-3H]thymidine 5' -triphosphate into DNA by an aliquot of centrifuged serum samples after it had been treated either with normal rabbit serum or with rabbit antibody to HBSAg. All of 58 serum samples containing e antigen revealed HBAg-associated DNA polymerase activity, whereas none of 96 samples containing anti-e did. In the remaining 249 samples in which neither e antigen nor anti-e was found, 62 showed specific DNA polymerase activity, although at lower levels than the samples containing e antigen.

Entities: Disease Species

Mesh：

Substances：

Year: 1976 PMID： 965088 PMCID： PMC420933 DOI： 10.1128/iai.14.3.631-635.1976

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

19 in total

Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system.

1. Bell's palsy and infectious mononucleosis.

2. Detection of additional antigenic determinants of hepatitis B antigen.

3. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants.

4. The heterogeneity of Australia antigen.

5. D.N.A. polymerase in preparations containing Australia antigen.

6. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis.

7. Hepatitis B core antigen. Detection of antibody by radioimmunoprecipitation.

8. Haemagglutination inhibition assay of the common determinants and subspecificities of Australia antigen.

9. New antigen-antibody system in Australia-antigen-positive hepatitis.

10. Dane particles, DNA polymerase, and e-antigen in two different categories of hepatitis B antigen carriers.

1. Comparison of indicators for dane particles.

2. Clinical significance of e-antigen/anti-e, with special reference to HBc-antigen in the liver.

Review 3. The hepatitis B virus and its DNA polymerase: the prototype three-D virus.

4. The relationship of hepatocellular carcinoma and liver cirrhosis to hepatitis B virus infection in the Philippines.

5. [Experiments for the development of a hepatitis B vaccine: immunogenicity of HBsAg in guinea pigs (author's transl)].

6. Hepatitis B e-antigen titres for evaluating infectivity during hepatitis B virus infection.

7. Anti-HBc, HBeAg and DNApolymerase activity in healthy HBsAg carriers and patients with inflammatory liver diseases.

8. e-Antigen: a link between immune response and infectivity in hepatitis B?

9. Viral antigens and antibodies in hepatitis B infection.

10. Hepatitis B e antigen and antibody in asymptomatic Chinese with hepatitis B surface antigenemia in Taiwan.