Literature DB >> 96467

Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward.

R J Katz, B J Carroll.   

Abstract

The centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C. 2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rats of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors.

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Year:  1978        PMID： 96467     DOI： 10.1007/bf00426955

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

Review 1.  Norepinephrine reward pathways: role of self-stimulation, memory consolidation, and schizophrenia.

Authors:  L Stein
Journal:  Nebr Symp Motiv       Date:  1975

2.  Intracranial self-stimulation at sites in the dorsal medulla oblongata.

Authors:  D A Carter; A G Phillips
Journal:  Brain Res       Date:  1975-08-22       Impact factor: 3.252

3.  Catecholamine concentration of discrete brain areas following self-stimulation in the ventromedial tegmentum of the rat.

Authors:  E Miliaressis; N B Thoa; Y Tizabi; D M Jacobowitz
Journal:  Brain Res       Date:  1975-12-12       Impact factor: 3.252

4.  Ascending monoamine-containing fiber pathways related to intracranial self-stimulation: histochemical fluorescence study.

Authors:  R M Clavier; A Routtenberg
Journal:  Brain Res       Date:  1974-05-31       Impact factor: 3.252

Review 5.  Catecholamine-containing neurones and electrical self-stimulation. 1. A review of some data.

Authors:  T J Crow
Journal:  Psychol Med       Date:  1972-11       Impact factor: 7.723

6.  Stereotaxic mapping of the monoamine pathways in the rat brain.

Authors:  U Ungerstedt
Journal:  Acta Physiol Scand Suppl       Date:  1971

7.  The contact method: a simple technique for electrical self-stimulation without external leads.

Authors:  G Wolf; L V Dicara; W Simpson
Journal:  Physiol Behav       Date:  1973-11

8.  Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro- -methylbenzylamine.

Authors:  R W Fuller; B W Roush; H D Snoddy; B B Molloy
Journal:  J Med Chem       Date:  1973-02       Impact factor: 7.446

9.  Inhibition of PNMT activity in the adrenal glands and brain stem of rats.

Authors:  J Y Lew; T Miyamoto; M Goldstein
Journal:  Biochem Pharmacol       Date:  1976-06-15       Impact factor: 5.858

10.  Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin.

Authors:  R J Katz; B J Carroll
Journal:  Psychopharmacology (Berl)       Date:  1977-01-31       Impact factor: 4.530
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  2 in total

1.  Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.

Authors:  I N Mefford; A L Lawrenz; J K Hsiao; J N Crawley
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol.

Authors:  M J Durcan; R G Lister; M Linnoila
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530
  2 in total

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