Literature DB >> 2502794

Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.

I N Mefford1, A L Lawrenz, J K Hsiao, J N Crawley.   

Abstract

LY134046, a potent, selective inhibitor of rat brain phenylethanolamine N-methyltransferase, was shown to increase activity in 18- and 19-day-old rats. The effects on day 25 were different, with LY134046 causing a decrease in activity. The effects of yohimbine, a selective antagonist of the alpha-2 adrenergic receptor, were markedly different from LY134046, causing a decrease in activity on day 19. These data suggest that epinephrine synthesis may play an inhibitory role in the regulation of activity in young rats.

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Year:  1989        PMID： 2502794     DOI： 10.1007/bf00444698

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  24 in total

1.  Ontogeny of alpha 1 and alpha 2-adrenoceptors in rat brain.

Authors:  M J Morris; J P Dausse; M A Devynck; P Meyer
Journal:  Brain Res       Date:  1980-05-19       Impact factor: 3.252

2.  Developmental changes in rat brain epinephrine levels.

Authors:  K H Milby; I N Mefford; R W Keller; R N Adams
Journal:  Brain Res       Date:  1979-06-22       Impact factor: 3.252

3.  Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.

Authors:  R W Fuller; S Hemrick-Luecke; R E Toomey; J S Horng; R R Ruffolo; B B Molloy
Journal:  Biochem Pharmacol       Date:  1981-06-01       Impact factor: 5.858

Review 4.  Nucleus locus ceruleus: new evidence of anatomical and physiological specificity.

Authors:  S L Foote; F E Bloom; G Aston-Jones
Journal:  Physiol Rev       Date:  1983-07       Impact factor: 37.312

5.  Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward.

Authors:  R J Katz; B J Carroll
Journal:  Psychopharmacology (Berl)       Date:  1978-04-14       Impact factor: 4.530

6.  Ontogeny of phenylethanolamine N-methyltransferase- and tyrosine hydroxylase-like immunoreactivity in presumptive adrenaline neurones of the foetal rat central nervous system.

Authors:  G A Foster; M Schultzberg; M Goldstein; T Hökfelt
Journal:  J Comp Neurol       Date:  1985-06-15       Impact factor: 3.215

7.  Brain stimulation reward: Evidence for an adrenergic contribution in the rat.

Authors:  R J Katz; B J Carroll
Journal:  Neurosci Lett       Date:  1977-07       Impact factor: 3.046

8.  Distribution of dopamine-, noradrenaline-, and adrenaline-containing cell bodies in the rat medulla oblongata: demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes.

Authors:  D M Armstrong; C A Ross; V M Pickel; T H Joh; D J Reis
Journal:  J Comp Neurol       Date:  1982-12-01       Impact factor: 3.215

9.  Rat medulla oblongata. III. Adrenergic (C1 and C2) neurons, nerve fibers and presumptive terminal processes.

Authors:  M Kalia; K Fuxe; M Goldstein
Journal:  J Comp Neurol       Date:  1985-03-15       Impact factor: 3.215

10.  Membrane properties and adrenergic responses in locus coeruleus neurons of young rats.

Authors:  J T Williams; K C Marshall
Journal:  J Neurosci       Date:  1987-11       Impact factor: 6.167
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