Literature DB >> 9632623

Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig.

M J Elhay1, T Oettinger, P Andersen.   

Abstract

Two antigens from Mycobacterium tuberculosis, ESAT-6 and MPT64, elicited delayed-type hypersensitivity (DTH) skin responses in outbred guinea pigs infected with M. tuberculosis by the aerosol and intravenous routes but not those sensitized with M. bovis BCG or M. avium. The DTH epitope of ESAT-6 was mapped to the C terminus. Nonresponders to the individual antigens were found, but all animals responded to a combination of ESAT-6 and MPT64 or their respective minimal target peptides. Correspondingly, these molecules could form the basis of a new skin test for tuberculosis.

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Year:  1998        PMID： 9632623      PMCID： PMC108370     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Human T-cell epitopes on the Mycobacterium tuberculosis secreted protein MPT64.

Authors:  P W Roche; C G Feng; W J Britton
Journal:  Scand J Immunol       Date:  1996-06       Impact factor: 3.487

2.  Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay.

Authors:  A B Andersen; Z L Yuan; K Hasløv; B Vergmann; J Bennedsen
Journal:  J Clin Microbiol       Date:  1986-03       Impact factor: 5.948

3.  Characterization of the delayed type hypersensitivity-inducing epitope of MPT64 from Mycobacterium tuberculosis.

Authors:  T Oettinger; A Holm; K Hasløv
Journal:  Scand J Immunol       Date:  1997-05       Impact factor: 3.487

4.  Comparison of the immunological activity of five defined antigens from Mycobacterium tuberculosis in seven inbred guinea pig strains. The 38-kDa antigen is immunodominant.

Authors:  K Hasløv; A B Andersen; L Ljungqvist; M Weis Bentzon
Journal:  Scand J Immunol       Date:  1990-04       Impact factor: 3.487

5.  B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis.

Authors:  M Harboe; A S Malin; H S Dockrell; H G Wiker; G Ulvund; A Holm; M C Jørgensen; P Andersen
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441

6.  Cross-reactions between mycobacteria. II. Crossed immunoelectrophoretic analysis of soluble antigens of BCG and comparison with other mycobacteria.

Authors:  M Harboe; R N Mshana; O Closs; G Kronvall; N H Axelsen
Journal:  Scand J Immunol       Date:  1979       Impact factor: 3.487

7.  Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents.

Authors:  J T Wilcke; B N Jensen; P Ravn; A B Andersen; K Hasløv
Journal:  Tuber Lung Dis       Date:  1996-06

8.  Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis.

Authors:  C Manca; K Lyashchenko; H G Wiker; D Usai; R Colangeli; M L Gennaro
Journal:  Infect Immun       Date:  1997-01       Impact factor: 3.441

9.  Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.

Authors:  M Harboe; T Oettinger; H G Wiker; I Rosenkrands; P Andersen
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

10.  Expression of Mycobacterium tuberculosis MPT64 in recombinant Myco. smegmatis: purification, immunogenicity and application to skin tests for tuberculosis.

Authors:  P W Roche; N Winter; J A Triccas; C G Feng; W J Britton
Journal:  Clin Exp Immunol       Date:  1996-02       Impact factor: 4.330
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  37 in total

1.  Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10.

Authors:  L A van Pinxteren; P Ravn; E M Agger; J Pollock; P Andersen
Journal:  Clin Diagn Lab Immunol       Date:  2000-03

2.  MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs.

Authors:  R Colangeli; J S Spencer; P Bifani; A Williams; K Lyashchenko; M A Keen; P J Hill; J Belisle; M L Gennaro
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

3.  Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle.

Authors:  H M Vordermeier; A Whelan; P J Cockle; L Farrant; N Palmer; R G Hewinson
Journal:  Clin Diagn Lab Immunol       Date:  2001-05

4.  An improved whole-blood gamma interferon assay based on the CFP21-MPT64 fusion protein.

Authors:  Ruiling Fu; Chun Wang; Chunwei Shi; Mengji Lu; Zhengming Fang; Jia Lu; Fang Wang; Xionglin Fan
Journal:  Clin Vaccine Immunol       Date:  2009-03-11

5.  Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response.

Authors:  T Mustafa; H G Wiker; O Mørkve; L Sviland
Journal:  Clin Exp Immunol       Date:  2007-08-17       Impact factor: 4.330

6.  Specific delayed-type hypersensitivity responses to ESAT-6 identify tuberculosis-infected cattle.

Authors:  J M Pollock; J McNair; H Bassett; J P Cassidy; E Costello; H Aggerbeck; I Rosenkrands; P Andersen
Journal:  J Clin Microbiol       Date:  2003-05       Impact factor: 5.948

7.  Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein family.

Authors:  Gareth J Jones; Stephen V Gordon; R Glyn Hewinson; H Martin Vordermeier
Journal:  Infect Immun       Date:  2010-01-19       Impact factor: 3.441

8.  Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant.

Authors:  Priscille Brodin; Karin Eiglmeier; Magali Marmiesse; Alain Billault; Thierry Garnier; Stefan Niemann; Stewart T Cole; Roland Brosch
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

9.  Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis.

Authors:  Donatella Vincenti; Stefania Carrara; Patrizia De Mori; Leopoldo P Pucillo; Nicola Petrosillo; Fabrizio Palmieri; Orlando Armignacco; Giuseppe Ippolito; Enrico Girardi; Massimo Amicosante; Delia Goletti
Journal:  Mol Med       Date:  2003 Mar-Apr       Impact factor: 6.354

10.  Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis.

Authors:  Tehmina Mustafa; Harald G Wiker; Odd Mørkve; Lisbet Sviland
Journal:  Virchows Arch       Date:  2008-02-12       Impact factor: 4.064
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